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Activation of Phosphoinositide 3-OH Kinase by the α6β4 Integrin Promotes Carcinoma Invasion
Abstract We demonstrate that the α6β4 integrin promotes carcinoma invasion through a preferential and localized targeting of phosphoinositide-3 OH kinase (PI3K) activity. Stable expression of α6β4Expand
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Ontology-Based Meta-Analysis of Global Collections of High-Throughput Public Data
Background The investigation of the interconnections between the molecular and genetic events that govern biological systems is essential if we are to understand the development of disease and designExpand
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Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion.
We demonstrate that the alpha6beta4 integrin promotes carcinoma invasion through a preferential and localized targeting of phosphoinositide-3 OH kinase (PI3K) activity. Stable expression ofExpand
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Prevalence of metaplasia at the gastro-oesophageal junction
Specialised columnar epithelium (SCE), a form of intestinal metaplasia usually found in Barrett's oesophagus, cannot be distinguished endoscopically from normal gastric epithelium. EndoscopistsExpand
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Phenotype of Barrett's Esophagus and Intestinal Metaplasia of the Distal Esophagus and Gastroesophageal Junction: An Immunohistochemical Study of Cytokeratins 7 and 20, Das-1 and 45MI
The pathogenesis of short segment Barrett's esophagus (SSBE) and intestinal metaplasia (IM) of the gastroesophageal junction (IMGEJ) are poorly understood. Also, these conditions are difficult toExpand
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Phenotypic Characteristics of a Distinctive Multilayered Epithelium Suggests That It Is a Precursor in the Development of Barrett's Esophagus
A distinctive type of multilayered epithelium (ME) has been described at the neo-squamocolumnar junction and within columnar mucosa in patients with Barrett's esophagus (BE). This epithelium hasExpand
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Induction of protective immunity against rabies by immunization with rabies virus ribonucleoprotein.
We have studied the ability of rabies virus ribonucleoprotein (RNP) to induce a protective immune response in animals against lethal challenge with rabies and rabies-related lyssa viruses. LiposomesExpand
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Prevalence and Significance of Inflammatory Bowel Disease-Like Morphologic Features in Collagenous and Lymphocytic Colitis
Collagenous colitis (CC) and lymphocytic colitis (LC) are clinical syndromes characterized by the presence of chronic watery diarrhea, few or no endoscopic abnormalities and biopsies that typicallyExpand
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Significance of acid-mucin-positive nongoblet columnar cells in the distal esophagus and gastroesophageal junction.
Acidic mucin-positive nongoblet columnar cells (NGCC) have recently been observed in the surface epithelium of the gastroesophageal junction (GEJ) and distal esophagus in resections from patientsExpand
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