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The accessible chromatin landscape of the human genome
The first extensive map of human DHSs identified through genome-wide profiling in 125 diverse cell and tissue types is presented, revealing novel relationships between chromatin accessibility, transcription, DNA methylation and regulatory factor occupancy patterns. Expand
The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints.
The findings are the first to demonstrate a link between a genetically defined subtype of cancer and its corresponding expression of immune checkpoints in the tumor microenvironment, and suggest that blockade of specific checkpoints may be selectively efficacious in the MSI subset of colorectal cancer. Expand
The genome of the pear (Pyrus bretschneideri Rehd.).
The draft genome of the pear using a combination of BAC-by-BAC and next-generation sequencing is reported, and size differences between the apple and pear genomes are confirmed mainly due to the presence of repetitive sequences predominantly contributed by transposable elements (TEs), while genic regions are similar in both species. Expand
Endometrial regenerative cells: A novel stem cell population
- X. Meng, T. Ichim, +9 authors N. Riordan
- Biology, Medicine
- Journal of Translational Medicine
- 15 November 2007
Mononuclear cells collected from the menstrual blood contained a subpopulation of adherent cells which could be maintained in tissue culture for >68 doublings and retained expression of the markers CD9, CD29, CD41a, CD44, CD59, CD73, CD90 and CD105, without karyotypic abnormalities. Expand
Reference genome sequence of the model plant Setaria
A high-quality reference genome sequence for foxtail millet (Setaria italica) is generated and regions of differential single-nucleotide polymorphism density, distribution of transposable elements, small RNA content, chromosomal rearrangement and segregation distortion are identified. Expand
A System for Real-time Twitter Sentiment Analysis of 2012 U.S. Presidential Election Cycle
- H. Wang, Dogan Can, Ebrahim (Abe) Kazemzadeh, F. Bar, Shrikanth S. Narayanan
- Computer Science
- 10 July 2012
A system for real-time analysis of public sentiment toward presidential candidates in the 2012 U.S. election as expressed on Twitter, a micro-blogging service, offers a new and timely perspective on the dynamics of the electoral process and public opinion. Expand
Current advances in research and clinical applications of PLGA-based nanotechnology
- Jianming Lü, Xinwen Wang, +4 authors Changyi J. Chen
- Expert review of molecular diagnostics
- 1 May 2009
More recent successes of applying PLGA-based nanotechnologies and tools in medicine-related applications are presented and the possible mechanisms, diagnosis and treatment effects of PLGA preparations and devices are focused on. Expand
A Temporal Chromatin Signature in Human Embryonic Stem Cells Identifies Regulators of Cardiac Development
It is shown that differentiation of human ESCs into cardiovascular cells is accompanied by programmed temporal alterations in chromatin structure that distinguish key regulators of cardiovascular development from other genes, and this temporal chromatin signature was used to identify regulators of cardiac development, including the homeobox gene MEIS2. Expand
Role of DNA Methylation in Modulating Transcription Factor Occupancy.
The results suggest that DNA methylation is not a primary groundskeeper of genomic TF landscapes, but rather a specialized mechanism for stabilizing intrinsically labile Sites, which are characterized by highly variable CTCF occupancy across cell types. Expand
Epithelial–Mesenchymal Transition (EMT) Induced by TNF-α Requires AKT/GSK-3β-Mediated Stabilization of Snail in Colorectal Cancer
It is revealed that AKT/GSK-3β-mediated stabilization of Snail is required for TNFα-induced EMT in CRC cells, and this study provides a better understanding of inflammation-induced CRC metastasis. Expand