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Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects
Alarm Bells The presence of DNA in the cytosol of mammalian cells is a danger signal, indicating, for example, that a DNA-containing virus has infected the cell. This signal triggers an innate immuneExpand
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Uncoupling protein-2 polymorphisms in type 2 diabetes, obesity, and insulin secretion.
The onset of type 2 diabetes (T2DM) is preceded by obesity, insulin resistance, and impaired beta-cell function. Uncoupling protein-2 (UCP2) is a widely expressed inner mitochondrial membraneExpand
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Physical activity and changes in weight and waist circumference in midlife women: findings from the Study of Women's Health Across the Nation.
Controversy exists regarding the extent to which age, menopausal status, and/or lifestyle behaviors account for the increased weight, fat mass, and central adiposity experienced by midlife women. ToExpand
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Identification of a receptor for BLyS demonstrates a crucial role in humoral immunity
B ymphocyte stimulator (BLyS) is a member of the tumor necrosis factor (TNF) superfamily. BLyS stimulates proliferation of, and immunoglobulin production by, B cells. However, the relative importanceExpand
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Analysis of the activation status of Akt, NFκB, and Stat3 in human diffuse gliomas
Loss of phosphatase and tensin homolog (PTEN) and amplification of the epidermal growth factor receptor (EGFR) gene contribute to the progression of gliomas. As downstream targets of the PTEN andExpand
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Non‐invasive prenatal testing of fetal whole chromosome aneuploidy by massively parallel sequencing
To determine whether non‐invasive prenatal testing by maternal plasma DNA sequencing can uncover all fetal chromosome aneuploidies in one simple sequencing event.
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Overexpression of TLR3, TLR4, TLR7 and TLR9 in esophageal squamous cell carcinoma.
AIM To investigate the expression of Toll-like receptor (TLR) 3, TLR4, TLR7 and TLR9 in esophageal squamous cell carcinoma (ESCC). METHODS Reverse transcription-polymerase chain reaction andExpand
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Human resistin gene: molecular scanning and evaluation of association with insulin sensitivity and type 2 diabetes in Caucasians.
Insulin resistance is strongly associated with obesity, but even among obese subjects insulin sensitivity varies widely. Recently, a new adipocyte hormone, resistin, was identified, shown to reduceExpand
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Diverse roles of invariant natural killer T cells in liver injury and fibrosis induced by carbon tetrachloride
Liver fibrosis is a common scarring response to all forms of chronic liver injury and is always associated with inflammation that contributes to fibrogenesis. Although a variety of cell populationsExpand
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Melatonin modulates TLR4‐mediated inflammatory genes through MyD88‐ and TRIF‐dependent signaling pathways in lipopolysaccharide‐stimulated RAW264.7 cells
Abstract:  Increasing evidence demonstrates that melatonin has an anti‐inflammatory effect. Nevertheless, the molecular mechanisms remain obscure. In this study, we investigated the effect ofExpand
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