Discontinuation of dasatinib in patients with chronic myeloid leukaemia who have maintained deep molecular response for longer than 1 year (DADI trial): a multicentre phase 2 trial.
Cutaneous colonization with staphylococci influences the disease activity of Sézary syndrome: a potential role for bacterial superantigens
Cutaneous colonization by S. aureus influences the disease activity of CTCL, possibly by activation of Sézary cells by bacterial superantigenic exoproteins.
Correlation Between Imatinib Pharmacokinetics and Clinical Response in Japanese Patients With Chronic‐Phase Chronic Myeloid Leukemia
Monitoring of IM levels in plasma may improve the efficacy of IM therapy for CML patients, and the data suggest that monitoring the level of IM in plasma should be monitored at least twice a year to improve the effectiveness of therapy.
Extranodal natural killer/T‐cell lymphoma, nasal type
The objective of this study was to investigate the correlation between local recurrence and radiotherapeutic parameters, including dose and RT radiotherapy (RT) field.
Shorter halving time of BCR‐ABL1 transcripts is a novel predictor for achievement of molecular responses in newly diagnosed chronic‐phase chronic myeloid leukemia treated with dasatinib: Results of…
- N. Iriyama, S. Fujisawa, H. Sakamaki
- Medicine, ChemistryAmerican journal of hematology/oncology
- 1 April 2015
It is shown that patients with CML‐CP treated with dasatinib can be stratified according to the early treatment response as determined by the halving time of BCR‐ABL1 transcripts.
Final 3‐year Results of the Dasatinib Discontinuation Trial in Patients With Chronic Myeloid Leukemia Who Received Dasatinib as a Second‐line Treatment
Roles of E‐ and P‐cadherin in the human skin
- F. Furukawa, K. Fujii, M. Takigawa
- Biology, MedicineMicroscopy research and technique (Print)
- 15 August 1997
The Ca2+‐dependent cell‐cell adhesion molecules, termed cadherins, are subdivided into several subclasses. E (epithelial)‐ and P (placental)‐cadherins are involved in the selective adhesion of…
Thrombin and trypsin induce granulocyte-macrophage colony-stimulating factor and interleukin-6 gene expression in cultured normal human keratinocytes.
It is speculated that serine proteases modulate the course of physiological and pathological processes in the skin by stimulating keratinocytes to produce the cytokines.
E‐ and P‐cadherin expression during murine hair follicle morphogenesis and cycling
It is suggested that isolated or combined E‐ and/or Pcad expression is involved in follicular pattern formation by segregating HF keratinocytes into functionally distinct subpopulations; most notably, isolated P cad expression may segregate those hair matrix keratinocyte into one functional epithelial tissue unit, which is particularly susceptible to growth control by dermal papilla‐derived morphogens.
Keratinocytes from patients with lupus erythematosus show enhanced cytotoxicity to ultraviolet radiation and to antibody‐mediated cytotoxicity
- F. Furukawa, T. Itoh, M. Takigawa
- Biology, MedicineClinical and Experimental Immunology
- 1 October 1999
It is shown that keratinocytes from patients with some forms of lupus erythematosus (SLE and SCLE) show greater cytotoxicity in vitro when irradiated with UVR, and greater susceptibility to ADCC whether the antibody source is their own serum or an anti‐SS‐A/Ro probe.