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Caseation of human tuberculosis granulomas correlates with elevated host lipid metabolism
TLDR
Molecular and biochemical evidence is provided that the development of the human TB granuloma to caseation correlates with pathogen‐mediated dysregulation of host lipid metabolism.
Staining of amyloid precursor protein to study axonal damage in mild head injury.
TLDR
Immunostaining with an antibody to amyloid precursor protein, a marker of fast axonal transport, showed multifocal axonal injury in all five patients and all had axonal damage in the fornices, which are important in memory function.
Topography of axonal injury as defined by amyloid precursor protein and the sector scoring method in mild and severe closed head injury.
TLDR
Analysis of the pattern of AI in the mild and severe head injury groups showed that axons were more vulnerable than blood vessels and that the axons in the corpus callosum and fornices were the most vulnerable of all.
Differential expression of iron-, carbon-, and oxygen-responsive mycobacterial genes in the lungs of chronically infected mice and tuberculosis patients
Pathogenetic processes that facilitate the entry, replication, and persistence of Mycobacterium tuberculosis (MTB) in the mammalian host likely include the regulated expression of specific sets of
Mycobacterium tuberculosis Growth at theCavity Surface: a Microenvironment with FailedImmunity
TLDR
The mutation profile of the isolates suggested that a single founder strain of Mycobacterium tuberculosis may undergo genetic changes during treatment, leading to acquisition of additional drug resistance independently in discrete physical locales.
Evaluation of alternative methods of cervical cancer screening for resource‐poor settings
Noncytologic methods of screening for cervical carcinoma and its precursor lesions are needed for resource‐poor settings in which cervical carcinoma continues to be an important cause of morbidity
Utility of quantitative T-cell responses versus unstimulated interferon-γ for the diagnosis of pleural tuberculosis
TLDR
Unstimulated IFN-γ was the most accurate test for distinguishing TB from non-TB effusions in a high-burden setting and the antigen-specific T-cell IGRAs were limited by suboptimal accuracy and the inability to isolate sufficient mononuclear cells to perform the assay.
Four decades of conjoined twins at Red Cross Children's Hospital--lessons learned.
TLDR
The prenatal diagnosis, obstetric implications and postnatal care of these children, including the relevant investigations and anaesthetic and surgical management, are discussed, with specific aspects related to the cardiovascular system, hepatobiliary and gastrointestinal tracts, urogenital tract, central nervous system and musculoskeletal system highlighted.
Quantitative lung T cell responses aid the rapid diagnosis of pulmonary tuberculosis
Background: The diagnosis of smear-negative pulmonary tuberculosis (TB) is problematic. There are limited data on the profile of alveolar TB antigen-specific T cells, and their utility for the rapid
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