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T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura
The data suggest that T-cell-mediated cytotoxicity is an alternative mechanism for platelet destruction in ITP and that cytotoxic cell-mediated lysis of autologous platelets was shown in active ITP.
Changes of plasma coagulation and fibrinolysis in response to mental stress.
- C. Jern, E. Eriksson, L. Tengborn, B. Risberg, H. Wadenvik, S. Jern
- Medicine, BiologyThrombosis and haemostasis
- 29 September 1989
It is concluded that mental stress has significant effects on plasma coagulation and fibrinolysis, and that it could thus affect important risk factors for cardiovascular disease.
Tyrosine kinase inhibitor usage, treatment outcome, and prognostic scores in CML: report from the population-based Swedish CML registry.
Patients living in university vs nonuniversity catchment areas more often received tyrosine kinase inhibitors up front but showed comparable survival, and high-risk scores were significantly linked to inferior overall and relative survival.
Increased cortical bone mineralization in imatinib treated patients with chronic myelogenous leukemia
- S. Jönsson, B. Olsson, C. Ohlsson, M. Lorentzon, D. Mellström, H. Wadenvik
- Biology, MedicineHaematologica
- 1 July 2008
Imatinib mesylate and the second generation ABL tyrosine kinase inhibitors have markedly improved the outcome of patients with chronic myeloid leukemia and more patients are receiving treatment with these inhibitors for prolonged periods of time.
IL1RAP antibodies block IL-1-induced expansion of candidate CML stem cells and mediate cell killing in xenograft models.
It is shown that primitive CML cells, in contrast to corresponding normal cells, express a functional interleukin-1 (IL-1) receptor complex and respond with NF-κB activation and marked proliferation in response to IL-1, which provides novel insights into the role of IL1RAP in CML.
Recruitment of T cells into bone marrow of ITP patients possibly due to elevated expression of VLA-4 and CX3CR1.
Recruitment of T cells into the target organ (eg, BM) is plausible and may be facilitated through increased VLA-4 and CX3CR1 expression and these molecules might serve as new treatment targets in ITP.
Diagnostic and differential criteria of essential thrombocythemia and reactive thrombocytosis.
The present authors propose the following novel criteria for the diagnosis of essential thrombocythemia, a distinct clinical entity in which an excessive number of morphologically and functionally abnormal platelets are produced.
Haematological changes during acute mental stress
- C. Jern, H. Wadenvik, H. Mark, J. Hallgren, S. Jern
- Medicine, BiologyBritish journal of haematology
- 1 January 1989
It is concluded that mental stress causes an increase in leucocyte and platelet count that could not solely be accounted for by the concurrent haemoconcentration.
Relapses in multiple sclerosis are associated with increased CD8+ T-cell mediated cytotoxicity in CSF
MicroRNA regulate immunological pathways in T-cells in immune thrombocytopenia (ITP).
Regulated microRNA were significantly associated with both gene and protein expression of molecules in immunological pathways, suggesting that microRNA may be important regulatory molecules involved in the loss of tolerance in ITP.