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Diastereoisomeric glucuronides of oxazepam. Isolation and stereoselective enzymic hydrolysis.
- H. W. Ruelius, C. Tio, J. Knowles, S. L. McHugh, R. Schillings, S. Sisenwine
- Chemistry, BiologyDrug metabolism and disposition: the biological…
The ready hydrolysis of one of the glucuronides by an enzyme from an intestinal microorganism may play a role in the enterohepatic circulation of oxazepam.
Bifidus factor. IV. Preparations obtained from human milk.
Carbohydrate oxidase, a novel enzyme from Polyporus obtusus. II. Specificity and characterization of reaction products.
Alcohol oxidase, a novel enzyme from a basidiomycete.
Clinical pharmacokinetics of lorazepam. I. Absorption and disposition of oral 14C-lorazepam.
Biotransformation to a pharmacologically inactive glucuronide metabolite appeared to be the major mechanism of lorazepam clearance and its metabolites in body fluids were determined by appropriate analytic techniques.
Clinical pharmacokinetics of lorazepam; II. Intramuscular injection
- D. Greenblatt, T. H. Joyce, H. W. Ruelius
- Medicine, PsychologyClinical pharmacology and therapeutics
- 1 February 1977
A single dose of 4 mg of lorazepam was injected into the deltoid muscles of six healthy male volunteers and all urine was collected for 24 hr after the dose, finding that less than 0.5% of the dose was recovered in the urine as lorZepam glucuronide and less than0.6% was recovered as unchanged lorzepam.
Clinical Pharmacokinetics of Lorazepam. III. Intravenous Injection. Preliminary Results
Four healthy male volunteers received 5 mg lorazepam as a single intravenous injection. Concentrations of lorazepam and its glucuronide metabolite were determined in multiple venous blood samples…
Disposition and metabolism of lorazepam in the male rat.
Evaluation of a DNA polymerase-deficient mutant of E. coli for the rapid detection of carcinogens.