H. W. Ruelius

Publications82
h-index24
Citations1,756
Highly Influential Citations20
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Bifidus factor. IV. Preparations obtained from human milk.
Abstract 1. 1. Cream, proteins, and salts can be removed from human milk with only small losses of bifidus activity. 2. 2. For the separation from lactose, processes have been developed using… Expand
Alcohol oxidase, a novel enzyme from a basidiomycete.
Carbohydrate oxidase, a novel enzyme from Polyporus obtusus. II. Specificity and characterization of reaction products.
Abstract 1. 1. Carbohydrate oxidase, an enzyme obtained from the mycelium of the Basidiomycete Polyporus obtusus, has been shown to catalyze the oxidation of several carbohydrates at the second… Expand
Diastereoisomeric glucuronides of oxazepam. Isolation and stereoselective enzymic hydrolysis.
Oxazepam glucuronide isolated from swine urine by previously published methods was separated into its diastereoisomers by ion-exchange chromatography on a preparative scale. Quantitative… Expand
Clinical pharmacokinetics of lorazepam; II. Intramuscular injection
A single dose of 4 mg of lorazepam was injected into the deltoid muscles of six healthy male volunteers. Multiple venous blood sampies were drawn during 48 hr after the dose and all urine was… Expand
Clinical Pharmacokinetics of Lorazepam. III. Intravenous Injection. Preliminary Results
Four healthy male volunteers received 5 mg lorazepam as a single intravenous injection. Concentrations of lorazepam and its glucuronide metabolite were determined in multiple venous blood samples… Expand
Alcohol oxidase, a flavoprotein from several Basidiomycetes species. Crystallization by fractional precipitation with polyethylene glycol.
Abstract 1. 1. A novel enzyme designated ‘alcohol oxidase’, has been isolated from the mycelium of a Basidiomycete belonging to the family Polyporaceae. In the presence of O2, this enzyme catalyzes… Expand
Disposition and metabolism of lorazepam in the male rat.
Evaluation of a DNA polymerase-deficient mutant of E. coli for the rapid detection of carcinogens.
Differential growth inhibition of two E. coli cultures was evaluated as a rapid screening technique for chemical carcinogens. Of the carcinogens tested, only "direct acting" carcinogens produced… Expand
Central nervous system and cardiovascular effects of lorazepam in man
A group of 15 healthy adult men was divided into three groups for a double‐blind study of the sedative‐hypnotic activity of single oral doses of lorazepam, a new member of the benzodiazepine series.… Expand
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