• Publications
  • Influence
CERAPP: Collaborative Estrogen Receptor Activity Prediction Project
Background: Humans are exposed to thousands of man-made chemicals in the environment. Some chemicals mimic natural endocrine hormones and, thus, have the potential to be endocrine disruptors. Most ofExpand
  • 128
  • 6
  • Open Access
Versatility or Promiscuity: The Estrogen Receptors, Control of Ligand Selectivity and an Update on Subtype Selective Ligands
The estrogen receptors (ERs) are a group of versatile receptors. They regulate an enormity of processes starting in early life and continuing through sexual reproduction, development, and end ofExpand
  • 43
  • 4
  • Open Access
Machine Learning Methods for Predicting HLA–Peptide Binding Activity
  • Heng Luo, H. Ye, +4 authors H. Hong
  • Medicine, Biology
  • Bioinformatics and biology insights
  • 1 January 2015
As major histocompatibility complexes in humans, the human leukocyte antigens (HLAs) have important functions to present antigen peptides onto T-cell receptors for immunological recognition andExpand
  • 31
  • 2
Whole genome sequencing of 35 individuals provides insights into the genetic architecture of Korean population
BackgroundDue to a significant decline in the costs associated with next-generation sequencing, it has become possible to decipher the genetic architecture of a population by sequencing a largeExpand
  • 29
  • 2
Structures of androgen receptor bound with ligands: advancing understanding of biological functions and drug discovery
ABSTRACT Introduction: Androgen receptor (AR) is a ligand-dependent transcription factor and a member of the nuclear receptor superfamily. It plays a vital role in male sexual development andExpand
  • 17
  • 2
sNebula, a network-based algorithm to predict binding between human leukocyte antigens and peptides
Understanding the binding between human leukocyte antigens (HLAs) and peptides is important to understand the functioning of the immune system. Since it is time-consuming and costly to measure theExpand
  • 13
  • 2
Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein.
  • H. Hong, W. Branham, +6 authors W. Tong
  • Biology, Medicine
  • Toxicological sciences : an official journal of…
  • 1 February 2015
One endocrine disruption mechanism is through binding to nuclear receptors such as the androgen receptor (AR) and estrogen receptor (ER) in target cells. The concentration of a chemical in serum isExpand
  • 44
  • 1
  • Open Access
Molecular Dynamics Simulations of the Adenosine A2a Receptor: Structural Stability, Sampling, and Convergence
Molecular dynamics (MD) simulations of membrane-embedded G-protein coupled receptors (GPCRs) have rapidly gained popularity among the molecular simulation community in recent years, a trend which hasExpand
  • 32
  • 1
  • Open Access
Development and Validation of Decision Forest Model for Estrogen Receptor Binding Prediction of Chemicals Using Large Data Sets.
Some chemicals in the environment possess the potential to interact with the endocrine system in the human body. Multiple receptors are involved in the endocrine system; estrogen receptor α (ERα)Expand
  • 27
  • 1
ehp CERAPP : Collaborative Estrogen Receptor Activity Prediction Project
Access to the published version may require subscription. Note to readers with disabilities: EHP will provide a 508-conformant version of this article upon final publication. If you require aExpand
  • 9
  • 1
  • Open Access