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Autophagy in immunity and inflammation
Autophagy is an essential, homeostatic process by which cells break down their own components. Perhaps the most primordial function of this lysosomal degradation pathway is adaptation to nutrientExpand
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Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
CRISPR-Cas9–based genetic screens are a powerful new tool in biology. By simply altering the sequence of the single-guide RNA (sgRNA), one can reprogram Cas9 to target different sites in the genomeExpand
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Complete sequence and genomic analysis of murine gammaherpesvirus 68.
Murine gammaherpesvirus 68 (gammaHV68) infects mice, thus providing a tractable small-animal model for analysis of the acute and chronic pathogenesis of gammaherpesviruses. To facilitate molecularExpand
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Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis
Exercise has beneficial effects on human health, including protection against metabolic disorders such as diabetes. However, the cellular mechanisms underlying these effects are incompletelyExpand
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Replication of Norovirus in Cell Culture Reveals a Tropism for Dendritic Cells and Macrophages
Noroviruses are understudied because these important enteric pathogens have not been cultured to date. We found that the norovirus murine norovirus 1 (MNV-1) infects macrophage-like cells in vivo andExpand
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STAT1-Dependent Innate Immunity to a Norwalk-Like Virus
Norwalk-like caliciviruses (Noroviruses) cause over 90% of nonbacterial epidemic gastroenteritis worldwide, but the pathogenesis of norovirus infection is poorly understood because these viruses doExpand
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Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins
LC3-associated phagocytosis (LAP) is a process wherein elements of autophagy conjugate LC3 to phagosomal membranes. We characterize the molecular requirements for LAP, and identify Rubicon as beingExpand
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Redefining Chronic Viral Infection
Viruses that cause chronic infection constitute a stable but little-recognized part of our metagenome: our virome. Ongoing immune responses hold these chronic viruses at bay while avoidingExpand
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Murine Norovirus: a Model System To Study Norovirus Biology and Pathogenesis
Human noroviruses are the major cause of nonbacterial, epidemic gastroenteritis worldwide ([19][1], [23][2], [33][3], [46][4]) and cause significant numbers of endemic cases, as well. One study fromExpand
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Regulation of starvation- and virus-induced autophagy by the eIF2α kinase signaling pathway
The eIF2α kinases are a family of evolutionarily conserved serine/threonine kinases that regulate stress-induced translational arrest. Here, we demonstrate that the yeast eIF2α kinase, GCN2, theExpand
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