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Induction of Long-Term Memory by Exposure to Novelty Requires Protein Synthesis: Evidence for a Behavioral Tagging
TLDR
It is demonstrated that weak inhibitory avoidance training, which induces short- but not long-term memory (LTM), can be consolidated into LTM by an exploration to a novel, but not a familiar, environment occurring close in time to the training session. Expand
Behavioral tagging is a general mechanism of long-term memory formation
TLDR
These findings represent the first comprehensive set of evidences indicating the existence of a behavioral tagging process that in analogy to the synaptic tagging and capture process, need the creation of a transient, protein synthesis-independent, and input specific tag. Expand
BDNF–triggered events in the rat hippocampus are required for both short‐ and long‐term memory formation
TLDR
The results indicate that endogenous BDNF is required for both STM and LTM formation of an inhibitory avoidance learning, and suggest that this requirement involves ERK1/2‐dependent and ‐independent mechanisms. Expand
The ubiquitin–proteasome cascade is required for mammalian long‐term memory formation
TLDR
It is shown that the hippocampal blockade of this proteolytic pathway is also required for the formation of long‐term memory in the rat, indicating that the ubiquitin–proteasome cascade is crucial for the establishment of LTM in the behaving animal. Expand
Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation
TLDR
An essential role of the induction of PRPs and learning tags for LTM formation is emphasized, as the existence of only the PRP or the tag was insufficient for stabilization of the mnemonic trace. Expand
Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects.
TLDR
It is demonstrated that apigenin is a ligand for the central benzodiazepine receptors exerting anxiolytic and slight sedative effects but not being anticonvulsant or myorelaxant. Expand
6-Methylapigenin and hesperidin: new valeriana flavonoids with activity on the CNS
TLDR
This paper is the first report of the presence of 2S(-)-hesperidin in valeriana and describes that it has sedative and sleep-enhancing properties, and 6-methylapigenin (MA) was found to have anxiolytic properties and was able to potentiate the sleep- enhancing properties of hesperidIn (HN). Expand
Role of hippocampal signaling pathways in long-term memory formation of a nonassociative learning task in the rat.
TLDR
It is suggested that memory formation of spatial habituation depends on the functional integrity of NMDA and AMPA/kainate receptors and CaMKII activity in the CA1 region of the hippocampus and that the detection of spatial novelty is accompanied by the activation of at least three different hippocampal protein kinase signaling cascades. Expand
Possible anxiolytic effects of chrysin, a central benzodiazepine receptor ligand isolated from Passiflora Coerulea
TLDR
The data suggest that chrysin possesses anxiolytic actions without inducing sedation and muscle relaxation, and postulate that this natural monoflavonoid is a partial agonist of the central BDZ receptors. Expand
Flavonoids and the Central Nervous System: from Forgotten Factors to Potent Anxiolytic Compounds
TLDR
Semisynthetic derivatives of flavone obtained by introducing halogens, nitro groups or both in its molecule give rise to high affinity ligands for the benzodiazepine receptor, active in‐vivo; 6,3′‐dinitroflavone, for example, is an anxiolytic drug 30 times more potent than diazepam. Expand
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