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Behavioral tagging is a general mechanism of long-term memory formation
We show that in rats subjected to weak training protocols that induce solely short term memory (STM), long term memory is promoted and formed only if training sessions took place in contingence with a novel, but not familiar, experience occurring during a critical time window around training. Expand
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Induction of Long-Term Memory by Exposure to Novelty Requires Protein Synthesis: Evidence for a Behavioral Tagging
A behavioral analog of the synaptic tagging and capture process, a key property of synaptic plasticity, has been predicted recently. Here, we demonstrate that weak inhibitory avoidance training,Expand
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The ubiquitin–proteasome cascade is required for mammalian long‐term memory formation
It has been recently demonstrated that ubiquitin–proteasome‐mediated proteolysis is required for long‐term synaptic facilitation in Aplysia. Here we show that the hippocampal blockade of thisExpand
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Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation
Long-term memory (LTM) consolidation requires the synthesis of plasticity-related proteins (PRPs). In addition, we have shown recently that LTM formation also requires the setting of a “learning tag”Expand
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BDNF–triggered events in the rat hippocampus are required for both short‐ and long‐term memory formation
Information storage in the brain is a temporally graded process involving different memory types or phases. It has been assumed for over a century that one or more short‐term memory (STM) processesExpand
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Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects.
The dried flower heads of Matricaria recutita L. (Asteraceae) are used in folk medicine to prepare a spasmolytic and sedative tea. Our fractionation of the aqueous extract of this plant led to theExpand
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Role of hippocampal signaling pathways in long-term memory formation of a nonassociative learning task in the rat.
Long-term habituation to a novel environment is one of the most elementary forms of nonassociative learning. Here we studied the effect of pre- or posttraining intrahippocampal administration ofExpand
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Possible anxiolytic effects of chrysin, a central benzodiazepine receptor ligand isolated from Passiflora Coerulea
The pharmacological effects of 5,7-dihydroxyflavone (chrysin), a naturally occurring monoflavonoid that displaces [3H]flunitrazepam binding to the central benzodiazepine (BDZ) receptors, wereExpand
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6-Methylapigenin and hesperidin: new valeriana flavonoids with activity on the CNS
Valerian is an ancient tranquillizing drug obtained from the underground organs of several Valeriana species. Its active principles were assumed to be terpenoids in the form of valepotriates and/orExpand
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Flavonoids and the Central Nervous System: from Forgotten Factors to Potent Anxiolytic Compounds
The list of activities of plant flavonoids did not include effects on the central nervous system (CNS) up to 1990, when our laboratory described the existence of natural anxiolytic flavonoids. TheExpand
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