• Publications
  • Influence
The endothelial glycocalyx: composition, functions, and visualization
This review aims at presenting state-of-the-art knowledge on the composition and functions of the endothelial glycocalyx. The endothelial glycocalyx is a network of membrane-bound proteoglycans andExpand
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Identification of distinct luminal domains for macromolecules, erythrocytes, and leukocytes within mammalian capillaries.
A thick endothelial surface coat consisting of the glycocalyx and associated plasma proteins has been hypothesized to reduce functional capillary volume available for flowing plasma macromoleculesExpand
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Mechanotransduction and flow across the endothelial glycocalyx
In this inaugural paper, we shall provide an overview of the endothelial surface layer or glycocalyx in several roles: as a transport barrier, as a porous hydrodynamic interface in the motion of redExpand
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The Endothelial Glycocalyx Protects Against Myocardial Edema
Myocardial tissue edema attributable to increased microvascular fluid loss contributes to cardiac dysfunction after myocardial ischemia, cardiopulmonary bypass, hypertension, and sepsis. RecentExpand
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Capillary endothelial surface layer selectively reduces plasma solute distribution volume.
  • H. Vink, B. Duling
  • Chemistry, Medicine
  • American journal of physiology. Heart and…
  • 2000
We previously reported that a 0.4- to 0.5-microm-thick endothelial surface layer confines Dextran 70 (70 kDa) to the central core of hamster cremaster muscle capillaries. In the present study we usedExpand
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Loss of endothelial glycocalyx during acute hyperglycemia coincides with endothelial dysfunction and coagulation activation in vivo.
Hyperglycemia is associated with increased susceptibility to atherothrombotic stimuli. The glycocalyx, a layer of proteoglycans covering the endothelium, is involved in the protective capacity of theExpand
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Endothelial Cell Glycocalyx Modulates Immobilization of Leukocytes at the Endothelial Surface
Objective—A thick endothelial glycocalyx provides the endothelial surface with a nonadherent shield. Oxidized LDL (Ox-LDL) degrades the endothelial glycocalyx. We hypothesized that glycocalyxExpand
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Vasculoprotective properties of the endothelial glycocalyx: effects of fluid shear stress
The endothelial glycocalyx exerts a wide array of vasculoprotective effects via inhibition of coagulation and leucocyte adhesion, by contributing to the vascular permeability barrier and by mediatingExpand
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Endothelial glycocalyx damage coincides with microalbuminuria in type 1 diabetes.
Chronic hyperglycemia underlies microvascular complications in patients with type 1 diabetes. The mechanisms leading to these vascular complications are not fully understood. Recently, we observedExpand
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Effect of sulodexide on endothelial glycocalyx and vascular permeability in patients with type 2 diabetes mellitus
Aims/hypothesisEndothelial glycocalyx perturbation contributes to increased vascular permeability. In the present study we set out to evaluate whether: (1) glycocalyx is perturbed in individuals withExpand
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