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The endothelial glycocalyx: composition, functions, and visualization
- S. Reitsma, D. Slaaf, H. Vink, Marc M. van Zandvoort, M. O. Oude Egbrink
- Biology, Medicine
- Pflügers Archiv - European Journal of Physiology
- 26 January 2007
This review aims at presenting state-of-the-art knowledge on the composition and functions of the endothelial glycocalyx. The endothelial glycocalyx is a network of membrane-bound proteoglycans and… Expand
Identification of distinct luminal domains for macromolecules, erythrocytes, and leukocytes within mammalian capillaries.
A thick endothelial surface coat consisting of the glycocalyx and associated plasma proteins has been hypothesized to reduce functional capillary volume available for flowing plasma macromolecules… Expand
Mechanotransduction and flow across the endothelial glycocalyx
- S. Weinbaum, Xiaobing Zhang, Y. Han, H. Vink, S. Cowin
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 16 June 2003
In this inaugural paper, we shall provide an overview of the endothelial surface layer or glycocalyx in several roles: as a transport barrier, as a porous hydrodynamic interface in the motion of red… Expand
The Endothelial Glycocalyx Protects Against Myocardial Edema
Myocardial tissue edema attributable to increased microvascular fluid loss contributes to cardiac dysfunction after myocardial ischemia, cardiopulmonary bypass, hypertension, and sepsis. Recent… Expand
Capillary endothelial surface layer selectively reduces plasma solute distribution volume.
We previously reported that a 0.4- to 0.5-microm-thick endothelial surface layer confines Dextran 70 (70 kDa) to the central core of hamster cremaster muscle capillaries. In the present study we used… Expand
Loss of endothelial glycocalyx during acute hyperglycemia coincides with endothelial dysfunction and coagulation activation in vivo.
Hyperglycemia is associated with increased susceptibility to atherothrombotic stimuli. The glycocalyx, a layer of proteoglycans covering the endothelium, is involved in the protective capacity of the… Expand
Endothelial Cell Glycocalyx Modulates Immobilization of Leukocytes at the Endothelial Surface
- A. Constantinescu, H. Vink, J. Spaan
- Chemistry, Medicine
- Arteriosclerosis, thrombosis, and vascular…
- 1 September 2003
Objective—A thick endothelial glycocalyx provides the endothelial surface with a nonadherent shield. Oxidized LDL (Ox-LDL) degrades the endothelial glycocalyx. We hypothesized that glycocalyx… Expand
Vasculoprotective properties of the endothelial glycocalyx: effects of fluid shear stress
- M. Gouverneur, B. Berg, M. Nieuwdorp, E. Stroes, H. Vink
- Journal of internal medicine
- 1 April 2006
The endothelial glycocalyx exerts a wide array of vasculoprotective effects via inhibition of coagulation and leucocyte adhesion, by contributing to the vascular permeability barrier and by mediating… Expand
Endothelial glycocalyx damage coincides with microalbuminuria in type 1 diabetes.
Chronic hyperglycemia underlies microvascular complications in patients with type 1 diabetes. The mechanisms leading to these vascular complications are not fully understood. Recently, we observed… Expand
Effect of sulodexide on endothelial glycocalyx and vascular permeability in patients with type 2 diabetes mellitus
Aims/hypothesisEndothelial glycocalyx perturbation contributes to increased vascular permeability. In the present study we set out to evaluate whether: (1) glycocalyx is perturbed in individuals with… Expand