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Age-related dopamine D2/D3 receptor loss in extrastriatal regions of the human brain
Loss of dopamine D2-like receptors in the striatum has been associated with both normal human aging and impairment of cognitive and motor functions in the elderly. To investigate whether there areExpand
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Depressive symptoms and presynaptic dopamine function in neuroleptic-naive schizophrenia
We have previously reported aberrations in the striatal presynaptic dopamine function in neuroleptic-naive schizophrenic patients compared to healthy controls (Hietala, J., Syvälahti, E., Vuorio, K.Expand
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Measurement of striatal and thalamic dopamine D2 receptor binding with 11C-raclopride
11C-Raclopride is a widely used positron emission tomography (PET) tracer for measurement of striatal D2 dopamine receptor binding characteristics. Recently, 11C-raclopride has also been used forExpand
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Striatal dopamine transporter binding in neuroleptic-naive patients with schizophrenia studied with positron emission tomography.
OBJECTIVE Recent in vivo imaging studies indicate a dysregulated presynaptic function of the striatal dopaminergic system in patients with schizophrenia. To further explore the basis of thisExpand
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High levels of dopamine activity in the basal ganglia of cigarette smokers.
OBJECTIVE The authors' goal was to study presynaptic dopamine activity in smoking and nonsmoking human subjects in vivo. METHOD [(18)F]Fluorodopa ([(18)F]DOPA) uptake K(i) values in the basalExpand
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Extrastriatal dopamine D2 and D3 receptors in early and advanced Parkinson’s disease
Objective: To investigate whether dopamine D2 and D3 receptor subtypes (D2/3Rs) outside the caudate-putamen are affected in PD. Background: Alterations in striatal D2-like dopamine receptors in PDExpand
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Cortical glutamate–dopamine interaction and ketamine-induced psychotic symptoms in man
RationaleThe noncompetitive glutamate N-methyl-d-aspartate receptor antagonist ketamine induces transient psychotic symptoms in man. Involvement of dopaminergic mechanisms in these effects has beenExpand
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Sex differences in striatal presynaptic dopamine synthesis capacity in healthy subjects
BACKGROUND There are sex differences in the clinical features of several neuropsychiatric illnesses associated with dopamine dysfunction. The effects of sex on brain dopaminergic function have beenExpand
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Striatal presynaptic dopamine function in type 1 alcoholics measured with positron emission tomography
Recent in vivo studies have shown low dopamine D2 receptor and dopamine transporter densities among late onset (type 1) alcoholics. We have now studied 6-[18F]-FDOPA (FDOPA) uptake in 10 type 1Expand
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Ketamine does not decrease striatal dopamine D2 receptor binding in man
Abstract Rationale. A glutamate–dopamine interaction has been implicated in the psychosis-like effects of glutamate N-methyl-D-aspartate (NMDA) receptor antagonists, such as phencyclidine andExpand
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