• Publications
  • Influence
Cardiovascular effects of (−)-11-OH-Δ8-tetrahydrocannabinol-dimethylheptyl in rats
TLDR
HU-210 shares with delta 9-tetrahydrocannabinol (THC) the ability to decrease BP and HR, but is 5-10 times more potent than the natural compound, possibly related to its specificity for the type-1 cannabinoid (CB1) receptor.
Cardiovascular effects of (-)-11-OH-delta 8-tetrahydrocannabinol-dimethylheptyl in rats.
TLDR
HU-210 shares with delta 9-tetrahydrocannabinol (THC) the ability to decrease BP and HR, but is 5-10 times more potent than the natural compound, possibly related to its specificity for the type-1 cannabinoid (CB1) receptor.
Cardiovascular effects of methamphetamine in dogs treated chronically with the amine.
  • H. Vidrio
  • Medicine
    Journal of cardiovascular pharmacology
  • 1 March 1982
TLDR
It was concluded that tolerance is not involved in the antihypertensive effect of methamphetamine and that, considering the stereo specificity of this effect, residual lowering of blood pressure might involve formation of a false mediator metabolite of the amine.
Endothelial Function Impairment in Chronic Venous Insufficiency: Effect of Some Cardiovascular Protectant Agents
TLDR
It was concluded that endothelial dysfunction is present in varicose veins, that this anomaly can be reverted by cardiovascular protecting agents, and that it can play a role in the pathogenesis and treatment of chronic venous insufficiency.
Pharmacology of Casimiroa edulis; III. Relaxant and contractile effects in rat aortic rings.
TLDR
The relaxant and contractile effects of an aqueous extract of the seeds of the hypotensive plant Casimiroa edulis were investigated in rat aortic rings and it was concluded that the relaxant effect is not exerted through release of an endothelial relaxing factor nor through blockade of calcium channels or of specific smooth muscle receptors, and does not involve histaminergic mechanisms.
Vascular tone and reactivity to serotonin in the internal and external carotid vascular beds of the dog.
  • H. Vidrio, E. Hong
  • Medicine
    The Journal of pharmacology and experimental…
  • 1 April 1976
TLDR
The results indicate that the internal and external carotid vascular beds of the dog react in opposite ways to serotonin, that both responses are mediated through the same type of serotonin receptors and that the dilator responses of the externalCarotid are dependent on vascular tone.
Pharmacology of Casimiroa edulis; Part I. Blood pressure and heart rate effects in the anesthetized rat.
TLDR
Experiments revealed that extract-induced hypotension was not mediated by histamine H2, muscarinic, or beta-adrenergic receptors, but involved an H1 mechanism and it was suggested that imidazole derivatives could be responsible for the depressor effect observed.
Endothelium protectant and contractile effects of the antivaricose principle escin in rat aorta.
TLDR
It was concluded that, in rat aorta, escin possesses an endothelium-protectant action and a direct contractile effect that could contribute to its beneficial effect in the treatment of venous insufficiency, while the latter could constitute a limiting side effect.
Pharmacology of Casimiroa edulis IV. Hypotensive effects of compounds isolated from methanolic extracts in rats and guinea pigs.
TLDR
It was concluded that hypotension produced by C. edulis is due to several active components, including histamine derivatives acting on H1-receptors and casimiroedine, which is partially offset by synephrine acetonide through adrenergic mechanisms.
Changing the countenance of pharmacology courses in medical schools.
TLDR
The clinician is particu-larly concerned with chemical en-tities that provoke human illness and those that possess selective biologic activity useful for the treatment of disease and the medical student is interested in learning the pharmaco-logical basis of therapeutics.
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