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Sphingolipids in food and the emerging importance of sphingolipids to nutrition.
There is no known nutritional requirement for sphingolipids; nonetheless, they are hydrolyzed throughout the gastrointestinal tract to the same categories of metabolites that are used by cells to regulate growth, differentiation, apoptosis and other cellular functions. Expand
Vitamin D status as an international issue: National surveys and the problem of standardization
Standardization activities will use single-donor, fresh-frozen serum collected using the CLSI C37 protocol, and initial assay performance criteria, based on biological variability data, are ≤10 % imprecision and ≤5 % bias in relation to the reference values. Expand
Challenges to the measurement of estradiol: an endocrine society position statement.
Although modern immunoassays and liquid chromatography/tandem mass spectrometry-based methods for estradiol are reasonably well suited to the diagnosis and management of infertility, the very low concentrations that appear to be crucial in nonreproductive tissues are a separate and more difficult issue. Expand
Validation of a food frequency questionnaire measurement of dietary acrylamide intake using hemoglobin adducts of acrylamide and glycidamide
Assessment of the validity of food frequency questionnaire (FFQ) measures of acrylamide intake calculated from an FFQ using a biomarker of acylamide exposure found within-person consistency in adducts was high over time. Expand
Reference ranges for testosterone in men generated using liquid chromatography tandem mass spectrometry in a community-based sample of healthy nonobese young men in the Framingham Heart Study and
Reference ranges generated in a community-based sample of men provide a rational basis for categorizing testosterone levels as low or normal and men with low TT or FT by these criteria had higher prevalence of physical dysfunction, sexual dysfunction, and diabetes. Expand
Traceability in laboratory medicine.
Establishing metrological traceability of measurement results satisfies basic clinical and public health needs, thus improving patient care and disease control and prevention, and addressing approaches for technical implementation of traceable methods as well as the associated challenges. Expand
Acylation of Naturally Occurring and Synthetic 1-Deoxysphinganines by Ceramide Synthase
Fumonisin B1 (FB1) is the predominant member of a family of mycotoxins produced byFusarium moniliforme (Sheldon) and related fungi. Certain foods also contain the aminopentol backbone (AP1) that isExpand
Harmonized Reference Ranges for Circulating Testosterone Levels in Men of Four Cohort Studies in the United States and Europe
Harmonization procedure reduced intercohort variation between testosterone measurements in men of similar ages, demonstrating the feasibility of generating harmonized reference ranges for testosterone that can be applied to assays, which have been calibrated to a reference method and calibrator. Expand
Standardization of immunoassays for measurement of high-sensitivity C-reactive protein. Phase I: evaluation of secondary reference materials.
All materials performed similarly with regard to imprecision, linearity, and parallelism, and because CRM470 had been certified previously as a reference material for the acute-phase reactant range, it will be used in the next phase to standardize hsCRP assays. Expand
Standardization of measurements of 25-Hydroxyvitamin D3 and D2
The available reference measurement system and its use as calibration hierarchy to establish traceability of measurements with routine laboratory methods to the SI-unit are described and other aspects considered essential for a successful and sustainable standardization are focused on. Expand