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Pharmacokinetics and bioavailability of different formulations of aciclovir.
TLDR
The pharmacokinetics and bioavailability of aciclovir (CAS 59277-89-3) were examined after administration of newly developed 200 mg and 400 mg tablets and the bioequivalence of a newly developed 400 mg acic Lovir tablet was tested against a standard product. Expand
New, high-sensitivity high-performance liquid chromatographic method for the determination of acyclovir in human plasma, using fluorometric detection.
TLDR
A high-performance liquid chromatographic method capable of determining acyclovir in plasma with sufficient sensitivity and for sufficiently long periods of time following oral administration of a standard dose of acy Clovir during pharmacokinetic investigations is developed. Expand
Hyponatraemia during psychopharmacological treatment: results of a drug surveillance programme.
TLDR
Plasma sodium levels below 130 mmol/l (severe HN according to AMSP) were reported in 93 patients during this period and Combinations of several drugs known to induce HN significantly increased the risk of HN, e.g. more than 10-fold for SSRI+diuretics+ACE inhibitors. Expand
Investigation on the bioequivalence of 2 oral preparations containing spironolactone and furosemide.
TLDR
The bioequivalence of 2 formulations containing spironolactone and furosemide was determined and the test formulation was found to be equivalent concerning the extent of bioavailability. Expand
Nonsteroidal antiinflammatory drugs and a selective cyclooxygenase 2 inhibitor uncouple mitochondria in intact cells.
TLDR
NSAIDs and selective COX-2 inhibitors have significant and equally directed effects on cellular energy metabolism and may not be sufficient to cause NSAID-like damage to the GI tract. Expand
Improved high-performance liquid chromatographic determination of amoxicillin in human plasma by means of column switching.
TLDR
The method can be used to determine pharmacokinetic parameters of amoxicillin in humans after a single oral dose of 500 mg and its suitability was demonstrated by the analysis of several hundred samples in a bioequivalence study. Expand
[The pharmacokinetics and bioequivalence of various dosage forms of ambroxol].
TLDR
The bioequivalence of ambroxol was investigated after administration of a newly developed vs. a commercial dose-equivalent, sustained- release dosage form and both sustained-release dosage forms investigated are bioequivalent. Expand
Putative mechanisms of cytoprotective effect of certain antacids and sucralfate
TLDR
It is likely that additional mechanisms and mediators other than prostaglandins, such as nonprotein sulfhydryls, also are involved in gastric cytoprotection arising from aluminum-containing antacids. Expand
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