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Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria
TLDR
Constitutive InsP(3)R Ca(2+) release to mitochondria is an essential cellular process that is required for efficient mitochondrial respiration and maintenance of normal cell bioenergetics.
A Polymorphism in CALHM1 Influences Ca2+ Homeostasis, Aβ Levels, and Alzheimer's Disease Risk
TLDR
It is proposed that CALHM1 encodes an essential component of a previously uncharacterized cerebral Ca(2+) channel that controls Abeta levels and susceptibility to late-onset AD.
Activation of Drosophila Sodium Channels Promotes Modification by Deltamethrin
TLDR
The super-kdr mutations effectively reduce the number of deltamethrin binding sites per channel from two to one, which reduces both the potency and efficacy of insecticide action.
Mutations in DIIS5 and the DIIS4–S5 linker of Drosophila melanogaster sodium channel define binding domains for pyrethroids and DDT
TLDR
DDT potency was unaffected by M918T, but abolished by T929I and reduced by L925I, L932F and I936V, suggesting that DIIS5 contains at least part of the DDT binding domain, and the data support a computer model of pyrethroid andDDT binding.
The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels.
TLDR
Studies of wild-type and mutant Na channels of insects and mammals are providing a molecular understanding of kdr and super-kdr resistance in insects, and of the low pyrethroid sensitivity of most mammalian Na channels.
Apoptosis regulation by Bcl-xL modulation of mammalian inositol 1,4,5-trisphosphate receptor channel isoform gating
TLDR
A redundancy among InsP3R isoforms in their ability to sensitize cells to apoptotic insults and to interact with Bcl-xL to modulate their activities that result in enhanced apoptosis resistance is demonstrated.
EMRE Is a Matrix Ca(2+) Sensor that Governs Gatekeeping of the Mitochondrial Ca(2+) Uniporter.
TLDR
EMRE-dependent regulation of MCU channel activity requires intermembrane space-localized MICU1, MICU2, and cytoplasmic Ca(2+) signaling, and mitochondria are protected fromCa(2+) depletion and Ca(1+) overload by a unique molecular complex that involves Ca( 2+) sensors on both sides of the inner mitochondrial membrane, coupled through EMRE.
Cloning and structure of delta-latroinsectotoxin, a novel insect-specific member of the latrotoxin family: functional expression requires C-terminal truncation.
TLDR
The primary structure of delta-latroinsectotoxin (delta-LIT), a novel insect-specific toxin from BWSV, is reported, suggesting that these toxins are a family of related proteins.
A single amino acid change makes a rat neuronal sodium channel highly sensitive to pyrethroid insecticides
TLDR
It is reported here that substitution of isoleucine for methionine at position 874 (equivalent to the super‐kdr site 918 in the housefly) in the rat IIA α‐subunit causes a 100‐fold increase in sensitivity.
Sensitivity of the Drosophila para sodium channel to DDT is not lowered by the super‐kdr mutation M918T on the IIS4–S5 linker that profoundly reduces sensitivity to permethrin and deltamethrin
TLDR
It is concluded that DDT binds either to or in the region of L1014 on IIS6 but only weakly to M918 on the IIS4–S5 linker, which is part of a high‐affinity binding site for permethrin and deltamethrin.
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