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Cardioprotective effect of metformin in lipopolysaccharide-induced sepsis via suppression of toll-like receptor 4 (TLR4) in heart.
Sepsis-induced myocardial dysfunction is a serious organ complication. In the present study, we investigated the effect of metformin on myocardial dysfunction and TLR4 activity in LPS-induced sepsis.Expand
Screening of Anti-Malarial Activity of Different Extracts Obtained from Three Species of Scrophularia Growing in Iran
Scrophularia genus belonging to the family of Scrophulariaceae, is a medicinal plant widely distributed in Iran. In the present study, the anti-malarial activity of different extracts of threeExpand
Zero flow global ischemia-induced injuries in rat heart are attenuated by natural honey.
PURPOSE In the present study, effects of preischemic administration of natural honey on cardiac arrhythmias and myocardial infarction size during zero flow global ischemia were investigated inExpand
Lipopolysaccharide Induced Activation of Toll Like Receptor 4 in Isolated Rat Heart Suggests a Local Immune Response in Myocardium.
BACKGROUND Myocardial dysfunction is one of the major complications in patients with sepsis where there is a relationship between the blood level of cytokines and the onset of myocardial depression.Expand
AMPK activation by metformin inhibits local innate immune responses in the isolated rat heart by suppression of TLR 4-related pathway.
Toll like receptors (TLRs) are key players in the innate immune responses. The energy sensing enzyme, AMPK, has been implicated in the modulation of immunity. The present study investigated whetherExpand
Attenuation of morphine-induced dependence and tolerance by ceftriaxone and amitriptyline in mice.
INTRODUCTION Tolerance to and dependence on the analgesic effect of opioids is a pharmacological phenomenon that occurs after their prolonged administration. OBJECTIVE The aim of this study was toExpand
Study the effects of hydroalcoholic extract of grape seed (Vitis vinifera ) on infarct size and cardiac arrhythmias in ischemic-reperfused isolated rat heart
Objectives : In the present study, effects of hydroalcoholic extract of grape seed (GSE) on ischemia-reperfusion (I/R)- induced infarct size and cardiac arrhythmias were investigated in isolated ratExpand
Metformin Alleviates Lipopolysaccharide-induced Acute Lung Injury through Suppressing Toll-like Receptor 4 Signaling.
Signaling AMP-activated protein kinase (AMPK), an energy sensing enzyme, has been implicated in controlling inflammation. In this study we investigated whether activation of AMPK by metformin couldExpand
A-769662, a direct AMPK activator, attenuates lipopolysaccharide-induced acute heart and lung inflammation in rats.
Activation of AMP‑activated protein kinase (AMPK) has been indicated to produce an anti‑inflammatory effect through the suppression of toll‑like receptor (TLR) activity. In the present study, theExpand