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UV-induced DNA damage, repair, mutations and oncogenic pathways in skin cancer.
- F. D. de Gruijl, H. V. van Kranen, L. H. Mullenders
- Biology, Medicine
- Journal of photochemistry and photobiology. B…
- 1 October 2001
Repair of UV induced DNA damage is of key importance to UV-induced skin carcinogenesis. Specific signal transduction pathways that regulate cell cycling, differentiation and apoptosis are found to be… Expand
Early p53 alterations in mouse skin carcinogenesis by UVB radiation: immunohistochemical detection of mutant p53 protein in clusters of preneoplastic epidermal cells.
- R. Berg, H. V. van Kranen, +5 authors F. D. de Gruijl
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 9 January 1996
High levels of the p53 protein are immunohistochemically detectable in a majority of human nonmelanoma skin cancers and UVB-induced murine skin tumors. These increased protein levels are often… Expand
The role of UV-B light in skin carcinogenesis through the analysis of p53 mutations in squamous cell carcinomas of hairless mice.
Mutation spectra of the p53 gene from human skin carcinomas have been connected to solar UV radiation. For comparison we have characterized the mutation spectrum of the p53 gene in a very large… Expand
Balancing the risks and benefits of drinking water disinfection: disability adjusted life-years on the scale.
- A. Havelaar, A. D. de Hollander, +5 authors W. Slob
- Environmental health perspectives
- 1 April 2000
To evaluate the applicability of disability adjusted life-years (DALYs) as a measure to compare positive and negative health effects of drinking water disinfection, we conducted a case study… Expand
Cigarette smoking and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition study.
- A. M. Leufkens, F. V. van Duijnhoven, +47 authors H. Bueno-de-Mesquita
- Clinical gastroenterology and hepatology : the…
- 1 February 2011
BACKGROUND & AIMS There has been consistent evidence for a relationship between smoking and colorectal cancer (CRC), although it is not clear whether the colon or rectum is more sensitive to the… Expand
Functional foods and dietary supplements: products at the interface between pharma and nutrition.
- S. Eussen, Helma Verhagen, +4 authors C. Rompelberg
- European journal of pharmacology
- 1 September 2011
It is increasingly recognized that most chronic diseases of concern today are multifactorial in origin. To combat such diseases and adverse health conditions, a treatment approach where medicines and… Expand
Integrated risk-benefit analyses: method development with folic acid as example.
- J. Hoekstra, J. Verkaik-Kloosterman, +4 authors N. de Jong
- Food and chemical toxicology : an international…
- 1 March 2008
With the introduction of novel and functional foods, there is increasing need for an integrated quantitative risk-benefit assessment of foods. Consensus about a quantitative risk-benefit assessment… Expand
Early p53-positive foci as indicators of tumor risk in ultraviolet-exposed hairless mice: kinetics of induction, effects of DNA repair deficiency, and p53 heterozygosity.
p53 mutations appear to be early events in skin carcinogenesis induced by chronic UVB irradiation. Clusters of epidermal cells that express p53 in mutant conformation ("p53 positive foci") are easily… Expand
Impact of global genome repair versus transcription-coupled repair on ultraviolet carcinogenesis in hairless mice.
The nucleotide excision repair (NER) system is comprised of two subpathways, i.e., transcription-coupled repair (TCR) and global genome repair (GGR). To establish the relative importance of TCR and… Expand
Discovery of common and rare genetic risk variants for colorectal cancer
To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence variants and Haplotype… Expand