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Intratracheal aerosolization of endotoxin (LPS) in the rat: a comprehensive animal model to study adult (acute) respiratory distress syndrome.
It is suggested that intratracheal LPS administration mimics the clinical development of ARDS very closely. Expand
Toxicokinetics of sulfur mustard and its DNA-adducts in the hairless guinea pig.
The toxicokinetics of this agent as well as its major DNA-adduct were studied in male hairless guinea pigs for the intravenous, respiratory and percutaneous routes to provide a quantitative basis for pretreatment and therapy of intoxications with sulfur mustard. Expand
Intravenous and inhalation toxicokinetics of sarin stereoisomers in atropinized guinea pigs.
The toxicokinetics of the stereoisomers of this nerve agent were studied in anesthetized, atropinized, and restrained guinea pigs after intravenous bolus administration and after nose-only exposure to vapor concentrations yielding 0.4 and 0.8 LCt50 of (+/-)-sarin. Expand
Percutaneous exposure to the nerve agent VX: Efficacy of combined atropine, obidoxime and diazepam treatment.
Percutaneous VX poisoning showed to be effectively treatable when diagnosed on time and when continued over the entire period of time during which VX, in case of ineffective decontamination, penetrates the skin. Expand
Long-term cognitive deficits accompanied by reduced neurogenesis after soman poisoning.
It is concluded that soman poisoning has long lasting effects on learning ability, a finding that was accompanied by impaired neurogenesis, and a correlation between impaired Neurogenesis and cognitive deficits is confirmed. Expand
Therapeutic efficacy of the adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA) against organophosphate intoxication
Investigating whether reduction of central acetylcholine (ACh) accumulation by adenosine receptor agonists could serve as a generic treatment against organophosphate (OP) poisoning demonstrated that CPA is highly effective against tabun or sarin poisoning, but fails to protect against VX or parathion. Expand
Pharmacological effects of oximes: how relevant are they?
A new concept for further treatment is suggested: maintenance of neuronal transmission in spite of continued AChE-inhibition by pharmacological manipulation of the cholinergic receptor. Expand
Stabilization and gas chromatographic analysis of the four stereoisomers of 1,2,2-trimethylpropyl methylphosphonofluoridate (soman) in rat blood.
A method for the stabilization and gas chromatographic analysis of the four stereoisomers of C(+/-)P(+/-)-1,2,2-trimethylpropyl methylphosphonofluoridate (C(+/-)P(+/-)-soman) in rat blood samples isExpand
Therapeutic efficacy of HI-6 in soman-poisoned marmoset monkeys.
HI-6 is an effective treatment against soman poisoning in marmosets and AChE reactivation or protection by HI-6 contributed to the survival of the animals. Expand
Aerosolized endotoxin is immediately bound by pulmonary surfactant protein D in vivo.
The lung collectin SP-D binds inhaled endotoxin in vivo, which may help to protect the lung from endotoxin-induced disease, and is concluded to be an LPS scavenging molecule in vivo. Expand