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Isolation and antihypertensive effect of angiotensin I-converting enzyme (ACE) inhibitory peptides from spinach Rubisco.
Four new inhibitory peptides for angiotensin I-converting enzyme (ACE), that is, MRWRD, MRW, LRIPVA, and IAYKPAG, were isolated from the pepsin-pancreatin digest of spinach Rubisco with the use of
Cardiovascular effects of capsaicin in dogs and rabbits.
TLDR
The findings suggest that the depressor re sponse of dogs and rabbits to Capsaicin is associated with cholinergic mechanisms, that capsaicin causes hypertension in dogs by its action on peripheral vasculatures but not on the heart and that capsicin-induced vasoconstriction is related intimately to extracellular Ca ++ but not to an adrenergic mechanism.
Design of a Highly Potent Anti-hypertensive Peptide Based on Ovokinin(2-7)
TLDR
RPLKPW, the most potent derivative obtained, showed significant anti-hypertensive activities at a dose of 0.1 mg/kg after oral administration in spontaneously hypertensive rats (SHRs), and showed 100-fold more potent anti- Hypertensive activity than ovokinin(2-7).
Designing Potent Derivatives of Ovokinin(2-7), an Anti-hypertensive Peptide Derived from Ovalbumin
TLDR
Oral administration in conscious spontaneously hypertensive rats (SHRs), [Pro2, Phe3]-ovokinin(2-7) significantly lowered the systolic blood pressure in a dose-dependent manner and proved to be an ideal, potent anti-hypertensive peptide with little effect on normal blood pressure when given orally.
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