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Liu-Jun-Zi-Tang, a kampo medicine, promotes adaptive relaxation in isolated guinea pig stomachs.
- T. Hayakawa, T. Arakawa, +8 authors K. Kobayashi
- Drugs under experimental and clinical research
Results suggested that Liu-Jun-Zi-Tang promoted gastric adaptive relaxation, which might, at least in part, contribute to the symptom relief in patients with functional dyspepsia. Expand
Pharmacological profiles of contractile endothelin receptors in guinea pig hilar bronchus.
It is suggested that ETB receptors primarily mediate contraction to ET-1, ET-3, STXc, and IRL 1620, and the relative inhibitory activities of ET antagonists vary with the agonist used. Expand
New aspects of gastric adaptive relaxation, reflex after food intake for more food: involvement of capsaicin-sensitive sensory nerves and nitric oxide.
- T. Arakawa, H. Uno, T. Fukuda, K. Higuchi, K. Kobayashi, T. Kuroki
- Chemistry, Medicine
- Journal of smooth muscle research = Nihon…
- 1 June 1997
In contrast with the pressure-induced adaptive relaxation, ganglionic nicotinic transmission is essential in the vagally induced relaxation, which is mediated by vagal motor fibers. Expand
Niacin attenuates acute lung injury induced by lipopolysaccharide in the hamster.
It is concluded that niacin attenuates LPS-induced acute lung injury, probably, in part, by preventing the depletion of NAD. Expand
[Evaluation of gastric adaptive relaxation in isolated stomach from the guinea-pig].
- H. Uno, T. Arakawa, +5 authors K. Kobayashi
- Nihon Shokakibyo Gakkai zasshi = The Japanese…
- 1 November 1995
Results suggest that GAR is mediated by NANC nerves, possibly via endogenous NO, and was abolished by tetrodotoxin in the presence of atropine and guanethidine and sodium nitroprusside induced the gastric relaxation. Expand
Involvement of capsaicin-sensitive sensory nerves in gastric adaptive relaxation in isolated guinea-pig stomachs.
It is suggested that activation of CPSNs may be involved in adaptive relaxation, and that NO, but not CGRP or VIP, may be involvement in the mechanisms of adaptive relaxation and receptive relaxation. Expand
Famotidine vs. omeprazole: a prospective randomized multicentre trial to determine efficacy in non‐erosive gastro‐oesophageal reflux disease
- Y. Fujiwara, K. Higuchi, +10 authors T. Arakawa
- Alimentary pharmacology & therapeutics
- 1 June 2005
The efficacy of acid‐suppressive drugs for non‐erosive gastro‐oesophageal reflux disease in Japan, in which the prevalence of Helicobacter pylori infection is higher compared with Western countries, is unknown. Expand
Effects of ranitidine on quality of gastric ulcer healing compared with famotidine: a randomized, controlled, multicenter trial.
- K. Higuchi, T. Watanabe, +9 authors T. Arakawa
- International journal of clinical pharmacology…
Initial therapy with ranitidine significantly improved the quality of gastric ulcer healing and the histological scores of Gastric mucosa compared with famotidine. Expand
Nitric oxide stimulates prostaglandin synthesis in cultured rabbit gastric cells.
It is suggested that NO increased PGE2 and PGI2 synthesis via a cGMP-independent pathway in cultured rabbit gastric cells. Expand
Pharmacological properties of a new centrally acting muscle relaxant (NC-1200) in isolated muscle preparations.
The present results are similar to the previous findings that the properties of serotonin, histamine and norepinephrine receptors in the rabbit aorta were different from those in other muscles. Expand