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Poly-l-Arginine Enhances Paracellular Permeability via Serine/Threonine Phosphorylation of ZO-1 and Tyrosine Dephosphorylation of Occludin in Rabbit Nasal Epithelium
AbstractPurpose. The purpose of the present study is to explore whether a poly-l-arginine (poly-l-Arg)-induced increase in tight junctions (TJ) permeability of fluorescein isothiocyanate-labeledExpand
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Acoustic cavitation as an enhancing mechanism of low-frequency sonophoresis for transdermal drug delivery.
We investigated the role of acoustic cavitation on sonophoretic skin permeation of calcein, a model permeant, across excised hairless rat skin. Three different frequencies (41, 158, 445 kHz) andExpand
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Characterization of systemic and histologic injury after crush syndrome and intervals of reperfusion in a small animal model.
BACKGROUND Prolonged compression of limb muscles and subsequent decompression are important in the development of crush syndrome (CS). We applied a simple rubber tourniquet to rat hind limbs toExpand
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Serotonin suppresses β-casein expression via inhibition of the signal transducer and activator of transcription 5 (STAT5) protein phosphorylation in human mammary epithelial cells MCF-12A.
Serotonin (5-hydroxytryptamine; 5-HT) has an important physiological role in controlling lactation, namely, milk volume homeostasis, within mammary glands. The objectives of this study were toExpand
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Development of a human mammary epithelial cell culture model for evaluation of drug transfer into milk
In the present study, a human mammary epithelial cell (HMEC) culture model was developed to evaluate the potential involvement of carrier-mediated transport systems in drug transfer into milk.Expand
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Poly-L-Arginine Predominantly Increases the Paracellular Permeability of Hydrophilic Macromolecules Across Rabbit Nasal Epithelium in Vitro
AbstractPurpose. The purpose of this work was to characterize the main transport pathway of hydrophilic macromolecules induced by poly-L-arginine (poly-L-Arg; molecular weight 42.4 kDa) across theExpand
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Change in the electrochemical properties of skin and the lipid packing in stratum corneum by ultrasonic irradiation
Effect of ultrasound on the skin permeation of benzoate anion (BA), a model compound, through excised hairless rat skin was investigated using electrochemical techniques. When the skin surface wasExpand
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Investigation of the release test method for the topical application of pharmaceutical preparations: release test of cataplasm including nonsteroidal anti-inflammatory drugs using artificial sweat.
A simple procedure for determining the in vitro release profile of a cataplasm for use in a quality control procedure has been developed. Since the disk assembly in the USP for patch dosage forms wasExpand
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Analysis of transient and reversible effects of poly-L-arginine on the in vivo nasal absorption of FITC-dextran in rats.
We have investigated whether poly-L-arginine, with a mean molecular weights of 8.9 and 45.5 kDa (poly-L-Arg (10) and poly-L-Arg (50)), can induce transient and reversible effects involvingExpand
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Skin penetration-enhancing effect of drugs by phonophoresis
The skin penetration enhancement of nine drugs by phonophoresis was analyzed using ultrasonic irradiation at 150 kHz in in vitro skin permeation experiments conducted to elucidate the flux andExpand
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