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S-nitrosothiol depletion in amyotrophic lateral sclerosis
The results suggest that SNO depletion disrupts the function and/or subcellular localization of proteins that are regulated by S-nitrosylation such as glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and thereby contributes to ALS pathogenesis. Expand
Inhibition of Chaperone Activity Is a Shared Property of Several Cu,Zn-Superoxide Dismutase Mutants That Cause Amyotrophic Lateral Sclerosis*
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive motor neuron degeneration, paralysis, and death. Mutant Cu,Zn-superoxide dismutase (SOD1) causes aExpand
Hydrophobically modified inulin as an amphiphilic carbohydrate polymer for micellar delivery of paclitaxel for intravenous route.
Self-assembling properties of a lauryl carbamate derivative of the poly-fructose natural polymer inulin (Inutec SP1(®) (INT) to form paclitaxel (PTX) loaded micelles are evaluated and INT offers safe, inexpensive and natural alternative to widely used PEG-modified polymers for the formulation of micellar delivery systems for pac litaxel. Expand
Identification of a novel skin penetration enhancement peptide by phage display peptide library screening.
The study identified a novel, safe, and noninvasive peptide to improve the skin penetration of drugs without chemical conjugation. Expand
Salicylic acid metabolites and derivatives inhibit CDK activity: Novel insights into aspirin's chemopreventive effects against colorectal cancer
It is suggested that intracellularly generated salicylic acid metabolites through CYP450 enzymes within the colonic epithelial cells, or the salicyolic acid metabolites generated by gut microflora may significantly contribute to the preferential chemopreventive effect of aspirin against CRC through inhibition of CDKs. Expand
Dendritic Cell-Targeted Nanovaccine Delivery System Prepared with an Immune-Active Polymer.
The current study demonstrates that the multifunctional InAc-based nanovaccine delivery system has potential applications in cancer immunotherapy and delivering vaccines against various infectious diseases. Expand
Multifunctional approaches utilizing polymeric micelles to circumvent multidrug resistant tumors.
stimulus-sensitive and multifunctional approaches to overcome MDR in cancer utilizing PMs are covered, which involve using single and/or combination of approaches to combat drug resistant. Expand
Development of soluble inulin microparticles as a potent and safe vaccine adjuvant and delivery system.
It is shown for the first time that water soluble inulins could be developed into vaccine adjuvants by formulating as antigen encapsulated microparticles as well as loading of the antigen. Expand
2-Deoxyglucose Induces Cell Cycle Arrest and Apoptosisin Colorectal Cancer Cells Independent of Its Glycolysis Inhibition
It is shown for the first time that 2DG induced a transient expression of p21 and a continuousexpression of p53 in colorectal cancer cells (SW620) and caused cell cycle arrest at G0/G1 phase and induced apoptosis through the mitochondrial pathway. Expand
Cyclin A2 and CDK2 as Novel Targets of Aspirin and Salicylic Acid: A Potential Role in Cancer Prevention
It is demonstrated that aspirin and salicylic acid downregulate cyclin A2/CDK2 proteins in multiple cancer cell lines, suggesting a novel target and mechanism of action in chemoprevention. Expand