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A family of mammalian Na+-dependent L-ascorbic acid transporters
TLDR
It is found that SVCT1 and SVCT2 each mediate concentrative, high-affinity L-ascorbic acid transport that is stereospecific and is driven by the Na+ electrochemical gradient. Expand
Molecular Cloning and Characterization of a Channel-like Transporter Mediating Intestinal Calcium Absorption*
TLDR
The properties of a calcium transport protein (CaT1) cloned from rat duodenum using an expression cloning strategy in Xenopus laevis oocytes are reported, which likely plays a key role in the intestinal uptake of calcium. Expand
Molecular Characterization of a Broad Selectivity Neutral Solute Channel*
TLDR
The expression cloning of a liver cDNA encoding a unique promiscuous solute channel (AQP9) that confers high permeability for both solute and water is reported, defining a new evolutionary branch of the major intrinsic protein family of aquaporin proteins and describing a previously unknown mechanism by which a large variety of solutes and water can pass through a single pore. Expand
Mutations in the formin protein INF2 cause focal segmental glomerulosclerosis
TLDR
Using linkage analysis, this work identified a locus for autosomal-dominant FSGS susceptibility on a region of chromosome 14q and detected nine independent nonconservative missense mutations in INF2, which encodes a member of the formin family of actin-regulating proteins. Expand
Functional and molecular characterization of the human neutral solute channel aquaporin-9.
TLDR
The data show that hAQP9 serves as a promiscuous solute channel expressed in both liver and peripheral leukocytes, where it is ideally suited to transport of metabolites and/or nutrients into and out of these cells. Expand
NPHS2 mutations in late-onset focal segmental glomerulosclerosis: R229Q is a common disease-associated allele.
TLDR
R229Q appears to enhance susceptibility to FSGS in association with a second mutant NPHS2 allele, which may define a subgroup of FSGS patients unresponsive to corticosteroids. Expand
Human vitamin C (L-ascorbic acid) transporter SVCT1.
TLDR
The molecular cloning of a novel human cDNA encoding a vitamin C transporter SVCT1 is described and it is demonstrated that the human SLC23A1 gene product is a related high-affinity l-ascorbic acid transporter (SVCT2) that is widely distributed in brain, retina, and a host of endocrine and neuroendocrine tissues. Expand
Cloning and characterization of the urea transporter UT3: localization in rat kidney and testis.
TLDR
Data suggest that UT3 in kidney is involved in counter current exchange between ascending and descending vasa recta, to enhance the cortico-papillary osmolality gradient. Expand
Molecular and functional analysis of SDCT2, a novel rat sodium-dependent dicarboxylate transporter.
TLDR
In situ hybridization revealed that SDCT2 is prominently expressed in kidney proximal tubule S3 segments and in perivenous hepatocytes, consistent with the sites of high-affinity dicarboxylate transport identified based on vesicle studies, and help to interpret the mechanisms of renal citrate transport, their alteration in pathophysiological conditions, and their role in the elimination of organic anions and therapeutic drugs. Expand
Phosphorylation of nephrin triggers its internalization by raft-mediated endocytosis.
TLDR
It is demonstrated that an RME pathway couples nephrin internalization to its own signaling, suggesting that RME promotes proper spatiotemporal assembly of slit diaphragms during podocyte development or injury. Expand
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