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Methamphetamine-related psychiatric symptoms and reduced brain dopamine transporters studied with PET.
OBJECTIVE A positron emission tomography (PET) study has suggested that dopamine transporter density of the caudate/putamen is reduced in methamphetamine users. The authors measured nucleus accumbensExpand
Brain serotonin transporter density and aggression in abstinent methamphetamine abusers.
CONTEXT In animals, methamphetamine is known to have a neurotoxic effect on serotonin neurons, which have been implicated in the regulation of mood, anxiety, and aggression. It remains unknownExpand
Association of dopamine transporter loss in the orbitofrontal and dorsolateral prefrontal cortices with methamphetamine-related psychiatric symptoms.
OBJECTIVE The authors examined dopamine transporter density in the orbitofrontal cortex, dorsolateral prefrontal cortex, and amygdala in methamphetamine users and assessed the relationship of theseExpand
Comparative effects of methamphetamine and nicotine on the striatal [11C]raclopride binding in unanesthetized monkeys
Although a very large literature exists on the in vitro, ex vivo, and in vivo effects of nicotine on dopamine release in rodents, similar data in primates are scant. This study was initiated toExpand
Neural Substrates of Human Facial Expression of Pleasant Emotion Induced by Comic Films: A PET Study
Laughter or smile is one of the emotional expressions of pleasantness with characteristic contraction of facial muscles, of which the neural substrate remains to be explored. Expand
Time-Dependent Central Compensatory Mechanisms of Finger Dexterity After Spinal Cord Injury
Transection of the direct cortico-motoneuronal pathway at the mid-cervical segment of the spinal cord in the macaque monkey results in a transient impairment of finger movements. Finger dexterityExpand
Chronic NMDA Antagonism Impairs Working Memory, Decreases Extracellular Dopamine, and Increases D1 Receptor Binding in Prefrontal Cortex of Conscious Monkeys
This study demonstrates that dizocilpine (MK-801), a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, impairs working memory of conscious behaving monkeys. In addition, acute andExpand
Effects of Binge Pattern Cocaine Administration on Dopamine D1 and D2 Receptors in the Rat Brain: AnIn Vivo Study Using Positron Emission Tomography
The aim of the present study was to determine the effect of “binge” pattern cocaine administration on dopamine D1and D2 receptors in the rat brain. Male Sprague Dawley rats were injected three timesExpand
Isoflurane anesthesia enhances the inhibitory effects of cocaine and GBR12909 on dopamine transporter: PET studies in combination with microdialysis in the monkey brain
The effects of the dopamine transporter (DAT) inhibitors cocaine and GBR12909 on DAT and dopamine D(2) receptors were evaluated in the brains under awake and isoflurane-anesthetized monkeys usingExpand
Is synaptic dopamine concentration the exclusive factor which alters the in vivo binding of [ 11 C ]raclopride?: PET studies combined with microdialysis in conscious monkeys
The effects of dopamine release manipulated by drugs on the in vivo binding of [11C]raclopride in the striatum were evaluated in conscious monkeys combined with microdialysis. The in vivo binding ofExpand