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alpha-Lipoic acid as a biological antioxidant.
alpha-Lipoic acid, which plays an essential role in mitochondrial dehydrogenase reactions, has recently gained considerable attention as an antioxidant. Lipoate, or its reduced form, dihydrolipoate,Expand
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The role of oxidative stress in the onset and progression of diabetes and its complications: asummary of a Congress Series sponsored byUNESCO‐MCBN, the American Diabetes Association and the German
This review summarises the results and discussions of an UNESCO‐MCBN supported symposium on oxidative stress and its role in the onset and progression of diabetes. There is convincing experimentalExpand
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Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB.
Activation of the transcription factor nuclear factor-kappaB (NF-kappaB) has been suggested to participate in chronic disorders, such as diabetes and its complications. In contrast to the short andExpand
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Neuroprotection by the Metabolic Antioxidant α-Lipoic Acid
Reactive oxygen species are thought to be involved in a number of types of acute and chronic pathologic conditions in the brain and neural tissue. The metabolic antioxidant alpha-lipoate (thiocticExpand
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Neuroprotection by the metabolic antioxidant alpha-lipoic acid.
Reactive oxygen species are thought to be involved in a number of types of acute and chronic pathologic conditions in the brain and neural tissue. The metabolic antioxidant alpha-lipoate (thiocticExpand
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Fatal familial insomnia, a prion disease with a mutation at codon 178 of the prion protein gene.
BACKGROUND We previously described two members of a family affected by an apparently genetically determined fatal disease characterized clinically by progressive insomnia, dysautonomia, and motorExpand
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The role of oxidative stress and NF‐κB activation in late diabetic complications
A common endpoint of hyperglycemia dependent cellular changes is the generation of reactive oxygen intermediates (ROIs) and the presence of elevated oxidative stress. Therefore, oxidative stress isExpand
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mtDNA depletion with variable tissue expression: a novel genetic abnormality in mitochondrial diseases.
We studied two related infants with a fatal mitochondrial disease, affecting muscle in one and liver in the other. Quantitative analysis revealed a severe depletion of mtDNA in affected tissues. ThisExpand
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Lipoic Acid Improves Nerve Blood Flow, Reduces Oxidative Stress, and Improves Distal Nerve Conduction in Experimental Diabetic Neuropathy
OBJECTIVE To determine whether lipoic acid (LA) will reduce oxidative stress in diabetic peripheral nerves and improve neuropathy. RESEARCH DESIGN AND METHODS We used the model ofExpand
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The Roles of Oxidative Stress and Antioxidant Treatment in Experimental Diabetic Neuropathy
Oxidative stress is present in the diabetic state. Our work has focused on its presence in peripheral nerves. Antioxidant enzymes are reduced in peripheral nerves and are further reduced in diabeticExpand
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