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Chitosan capsules for colon-specific drug delivery: improvement of insulin absorption from the rat colon.
TLDR
It is suggested that chitosan capsules may be useful carriers for the colon-specific delivery of peptides including insulin, as evaluated by the transit time experiments with chitOSan capsules. Expand
Chitosan capsules for colon-specific drug delivery: enhanced localization of 5-aminosalicylic acid in the large intestine accelerates healing of TNBS-induced colitis in rats.
TLDR
Chitosan capsules may be useful carriers for the colon-specific delivery of anti-inflammatory drugs including 5-ASA and the healing of TNBS-induced colitis in rats. Expand
Use of Protease Inhibitors to Improve Calcitonin Absorption from the Small and Large Intestine in Rats
TLDR
The objective of this study was to examine the effects of protease inhibitors on the absorption of calcitonin from different regions of the intestine in rats by in‐situ use of closed intestinal loops and stability of calcite was examined in mucosal homogenates and intestinal fluids. Expand
Degradation of Insulin and Calcitonin and Their Protection by Various Protease Inhibitors in Rat Caecal Contents: Implications in Peptide Delivery to the Colon
The objective of this study was to examine the metabolism of insulin and calcitonin, and their protection by various protease inhibitors, in the large intestine.
Chitosan Capsules for Colon-Specific Drug Delivery: Improvement of Insulin Absorption from the Rat Colon
The objective of this study was to estimate colon-specific insulin delivery with chitosan capsules. In vitro drug release experiments from chitosan capsules containing 5(6)-carboxyfluorescein (CF)Expand
Colon-specific delivery of R68070, a new thromboxane synthase inhibitor, using chitosan capsules: therapeutic effects against 2,4,6-trinitrobenzene sulfonic acid-induced ulcerative colitis in rats.
TLDR
Results suggest that chitosan capsule might be a very useful dosage form for the colon-specific delivery of R68070 as an anti-inflammatory drug and for the therapy of ulcerative colitis. Expand
Validation of a Pharmacokinetic Model of Colon‐specific Drug Delivery and the Therapeutic Effects of Chitosan Capsules Containing 5‐Aminosalicylic Acid on 2,4,6‐Trinitrobenzenesulphonic Acid‐induced
A pharmacokinetic model of colon‐specific drug delivery developed in a previous study has been validated by use of 5‐aminosalicylic acid (5‐ASA) as a model anti‐inflammatory drug.
Colon-specific delivery of peptide drugs and anti-inflammatory drugs using chitosan capsules
Nous avons etudie la delivrance specifique au niveau du colon de principes actifs peptidique ou anti-irfammatoire par des capsules de chitosan. Une faible liberation in vitro deExpand
Colon‐specific Delivery of Budesonide with Azopolymer‐coated Pellets: Therapeutic Effects of Budesonide with a Novel Dosage Form against 2,4,6‐Trinitrobenzenesulphonic Acid‐induced Colitis in Rats
The objective of this study was to achieve colon‐specific delivery of budesonide using azopolymer‐coated pellets and to accelerate healing of 2,4,6‐trinitrobenzenesulphonic acid sodium saltExpand
Enhanced absorption of insulin and (Asu(1,7))eel-calcitonin using novel azopolymer-coated pellets for colon-specific drug delivery.
TLDR
It is suggested that azopolymer-coated pellets may be useful carriers for the colon-specific delivery of peptides including insulin and (Asu(1,7))eel-calcitonin. Expand
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