Author pages are created from data sourced from our academic publisher partnerships and public sources.
Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors.
Lysophosphatidic acid (LPA) exerts a variety of biological responses through specific receptors: three subtypes of the EDG-family receptors, LPA1, LPA2, and LPA3 (formerly known as EDG-2, EDG-4, and… Expand
Biophysical characteristics of HIMAC clinical irradiation system for heavy-ion radiation therapy.
- T. Kanai, M. Endo, +12 authors K. Kawachi
- International journal of radiation oncology…
- 1 April 1999
PURPOSE The irradiation system and biophysical characteristics of carbon beams are examined regarding radiation therapy. METHODS AND MATERIALS An irradiation system was developed for heavy-ion… Expand
Molecular Cloning of a Novel Brain‐Type Na+‐Dependent Inorganic Phosphate Cotransporter
Abstract: We have isolated a human cDNA encoding a protein, designated DNPI, that shows 82% amino acid identity and 92% similarity to the human brain‐specific Na+‐dependent inorganic phosphate… Expand
TDAG8 Is a Proton-sensing and Psychosine-sensitive G-protein-coupled Receptor*
- Ju-Qiang Wang, J. Kon, +18 authors F. Okajima
- Medicine, Chemistry
- Journal of Biological Chemistry
- 29 October 2004
T cell death-associated gene 8 (TDAG8) has been reported to be a receptor for psychosine. Ovarian cancer G-protein-coupled receptor 1 (OGR1) and GPR4, G-protein-coupled receptors (GPCRs) closely… Expand
Mutations in the small heterodimer partner gene are associated with mild obesity in Japanese subjects.
- H. Nishigori, H. Tomura, +18 authors J. Takeda
- Medicine, Biology
- Proceedings of the National Academy of Sciences…
- 16 January 2001
Mutations in several genes encoding transcription factors of the hepatocyte nuclear factor (HNF) cascade are associated with maturity-onset diabetes of the young (MODY), a monogenic form of… Expand
Identification of mutations in the hepatocyte nuclear factor-1alpha gene in Japanese subjects with early-onset NIDDM and functional analysis of the mutant proteins.
Each one of certain histidine residues in G-protein-coupled receptor GPR4 is critical for extracellular proton-induced stimulation of multiple G-protein-signaling pathways.
GPR4, previously proposed as the receptor for sphingosylphosphorylcholine, has recently been identified as the proton-sensing G-protein-coupled receptor coupling to multiple intracellular signaling… Expand
Sphingosine 1-Phosphate Receptors Mediate the Lipid-Induced cAMP Accumulation through Cyclooxygenase-2/Prostaglandin I2 Pathway in Human Coronary Artery Smooth Muscle Cells
- Alatangaole Damirin, H. Tomura, +6 authors F. Okajima
- Medicine, Biology
- Molecular Pharmacology
- 1 April 2005
Sphingosine 1-phosphate (S1P) has been shown to exert a variety of biological responses through extracellular specific receptors or intracellular mechanisms. In the present study, we characterized a… Expand
LPA1 receptors mediate stimulation, whereas LPA2 receptors mediate inhibition, of migration of pancreatic cancer cells in response to lysophosphatidic acid and malignant ascites.
Malignant ascites from pancreatic cancer patients has been reported to stimulate migration of pancreatic cancer cells through lysophosphatidic acid (LPA) and LPA(1) receptors. Indeed, ascites- and… Expand
Mutation analysis of NR0B2 among 1545 Danish men identifies a novel c.278G>A (p.G93D) variant with reduced functional activity
Variations of the small heterodimer partner (SHP, NR0B2) gene, an atypical nuclear receptor that inhibits transactivation by hepatocyte nuclear factor (HNF)‐4α, are associated with obesity among… Expand