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In vivo biological behavior of a water-miscible fullerene: 14C labeling, absorption, distribution, excretion and acute toxicity.
Estrogen receptor binding assay method for endocrine disruptors using fluorescence polarization.
A rapid, simple and nonhazardous assay method for endcrine disruptors was developed using an estrogen receptor (ER) and fluorescence polarization (FP) using the 17alpha-fluorescein-labeled estradiol derivative as the most suitable ligand for the ER binding assay.
Structure and biological function of ENPP6, a choline-specific glycerophosphodiester-phosphodiesterase
The present study provides the molecular basis for ENPP6-mediated choline metabolism at atomic, cellular and tissue levels and reveals that the choline moiety of the phosphocholine is recognized by a choline-binding pocket formed by conserved aromatic and acidic residues.
Biological Activity of Water-Soluble Fullerenes. Structural Dependence of DNA Cleavage, Cytotoxicity, and Enzyme Inhibitory Activities Including HIV-Protease Inhibition
Two different classes of water-soluble fullerene derivatives, detergent-type and sphere-type, were synthesized and found to be photo-inactive with respect to DNA cleaving activity and cytotoxicity and potent HIV protease inhibitor.
Photoinduced biochemical activity of fullerene carboxylic acid
It is found that even low-energy visible light is surfficient to induce biological activity in fullerene derivatives, suggesting that fullerenes may serve as useful photosensitive biochemical probes.
Fullerene–Oligonucleotide Conjugates: Photoinduced Sequence‐Specific DNA Cleavage
Regioselective synthesis of heterocycles containing nitrogen neighboring an aromatic ring by reductive ring expansion using diisobutylaluminum hydride and studies on the reaction mechanism.
- Hidetsura Cho, Yusuke Iwama, Kenji Sugimoto, S. Mori, H. Tokuyama
- ChemistryThe Journal of organic chemistry
- 5 February 2010
It was found that the more electron-rich group migrated preferentially to give the corresponding secondary amines in the reductive ring-expansion reaction of cyclic ketoximes fused to aromatic rings with diisobutylaluminum hydride.
Stereocontrolled total synthesis of (-)-eudistomin C.
- Tohru Yamashita, N. Kawai, H. Tokuyama, T. Fukuyama
- ChemistryJournal of the American Chemical Society
- 7 October 2005
A stereocontrolled total synthesis of (-)-eudistomin C was accomplished in 18-step sequence with an overall yield of 7.7% and the unprecedented construction of the unusual oxathiazepine ring by intramolecular alkylation.
Radical Cyclization of 2-Alkenylthioanilides: A Novel Synthesis of 2,3-Disubstituted Indoles
Facile Palladium-Mediated Conversion of Ethanethiol Esters to Aldehydes and Ketones
- H. Tokuyama, S. Yokoshima, Tohru Yamashita, Lin Shao-Cheng, L. Leping, T. Fukuyama
- 1 August 1998
Treatment of ethanethiol esters with triethylsilane and palladium on carbon at ambient temperature furnished aldehydes. In addition, a variety of ketones have been prepared by a palladium-catalyzed…