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KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II.
Results suggest that KN-62 affects the interaction between calmodulin and Ca2+/CaM kinase II following inhibition of this kinase activity by directly binding to theCalmodulin binding site of the enzyme but does not affect the cal modulin-independent activity of already autophosphorylated (activated) enzyme. Expand
STO-609, a Specific Inhibitor of the Ca2+/Calmodulin-dependent Protein Kinase Kinase*
Results indicate that STO-609 is a selective and cell-permeable inhibitor of CaM-KK and that it may be a useful tool for evaluating the physiological significance of the CaM/calmodulin-dependent protein kinase kinase pathway in vivo as well as in vitro. Expand
Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway
A Ca2+/calmodulin-dependent protein kinase kinase (CaM-KK) activates PKB directly, resulting in phosphorylation of BAD on serine residue 136 and the interaction of BAD with protein 14-3-3, which protects cells from apoptosis. Expand
Calmodulin-Kinases: Modulators of Neuronal Development and Plasticity
In Figure 1, it is Caspase-1 that cleaves IL-1b, not Caspase-3 as labeled.
Regulation of Axonal Extension and Growth Cone Motility by Calmodulin-Dependent Protein Kinase I
It is reported that inhibition of cytosolic CaMKI, but not CaMKII or nuclear CaMKIV, dramatically decreases axonal outgrowth and branching in cultured neonatal hippocampal and postnatal cerebellar granule neurons. Expand
Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade.
A new Ca2+-dependent mechanism for regulating MAP kinase pathways and resultant transcription is established byutation of the phosphorylation site in CaM-KIV, which prevented activation of Elk-1, c-Jun, and ATF2 by the CaM kinase cascade. Expand
NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymus
The expression pattern of NFATx, together with its functional activity, strongly suggests thatNFATx plays a role in the regulation of gene expression in T cells and immature thymocytes. Expand
A CaMK cascade activates CRE‐mediated transcription in neurons of Caenorhabditis elegans
It is reported that all components of this CaMK cascade are coexpressed in head neurons of Caenorhabditis elegans and regulates CRE‐mediated transcription in a subset of head neurons in living nematodes. Expand
Analysis of CaM-kinase signaling in cells.
This review will outline several protocols used to identify which members and/or isoforms of this CaMK family mediate specific cellular responses with a focus on studies in neurons. Expand
A novel target recognition revealed by calmodulin in complex with Ca2+-calmodulin-dependent kinase kinase
The structure of calcium-bound calmodulin (Ca2+/CaM) complexed with a 26-residue peptide, corresponding to the CaM-binding domain of rat Ca2+/CaM-dependent protein kinase kinase (CaMKK), has beenExpand