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daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans.
Life-span regulation by insulin-like metabolic control is analogous to mammalian longevity enhancement induced by caloric restriction, suggesting a general link between metabolism, diapause, and longevity. Expand
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
In Caenorhabditis elegans, mutations that reduce the activity of an insulin-like receptor (daf-2) or a phosphatidylinositol-3-OH kinase (age-1) favour entry into the dauer state during larvalExpand
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
It is shown that null mutations in Daf-16 suppress the effects of mutations in daf-2 or age-1; lack of dAF-16 bypasses the need for this insulin receptor-like signalling pathway. Expand
A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans
It is suggested that phosphatidylinositol signalling mediated by AGE-1 protein controls lifespan and the dauer diapause decision. Expand
JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16.
This work demonstrates that c-Jun N-terminal kinase (JNK) is a positive regulator of DAF-16 in both lifespan regulation and stress resistance and defines an interaction between two well conserved proteins, JNK-1 and D AF-16, and provides a mechanism by which JNK regulates longevity and stress Resistance. Expand
RTEL1 Maintains Genomic Stability by Suppressing Homologous Recombination
C. elegans RTEL-1 is identified as a functional analog of Srs2 and its vertebrate counterpart, RTEL1, is described, which is required for genome stability and tumor avoidance and proposed as a critical event that drives genome instability and cancer. Expand
A new DAF-16 isoform regulates longevity
It is shown that DAF-16 isoforms functionally cooperate to modulate IIS-mediated processes through differential tissue enrichment, preferential modulation by upstream kinases, and regulating distinct and overlapping target genes. Expand
Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation
The results show that the ChIP-based cloning strategy leads to greater enrichment for DAF-16 target genes than previous screening strategies, and it is demonstrated that Daf-16 is recruited to multiple promoters to coordinate regulation of its downstream targets. Expand
Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO
The data defines a central role for C. elegans SIR2 in regulation of life span by caloric restriction and demonstrates that sir-2.1 and daf-16 have both overlapping and distinct functions in regulated life span regulation. Expand
A PP2A Regulatory Subunit Regulates C. elegans Insulin/IGF-1 Signaling by Modulating AKT-1 Phosphorylation
A conserved role for the B56 regulatory subunit in regulating insulin signaling through AKT dephosphorylation is revealed, thereby having widespread implications in cancer and diabetes research. Expand