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HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium.
- H. Taylor, A. Arıcı, D. Olive, P. Igarashi
- Biology, MedicineThe Journal of clinical investigation
- 1 April 1998
Results identify sex steroids as novel regulators of HOX gene expression and HOXA10 may have an important function in regulating endometrial development during the menstrual cycle and in establishing conditions necessary for implantation in the human.
Effects of Hormone Therapy on Cognition and Mood in Recently Postmenopausal Women: Findings from the Randomized, Controlled KEEPS–Cognitive and Affective Study
The KEEPS-Cog findings suggest that for recently postmenopausal women, MHT did not alter cognition as hypothesized, and women treated with o-CEE showed improvements in depression and anxiety symptoms over the 48 mo period, compared to women on placebo.
In Utero Exposure to Diethylstilbestrol (DES) or Bisphenol-A (BPA) Increases EZH2 Expression in the Mammary Gland: An Epigenetic Mechanism Linking Endocrine Disruptors to Breast Cancer
- L. Doherty, J. Bromer, Yuping Zhou, Tamir S. Aldad, H. Taylor
- Biology, MedicineHormones & cancer
- 15 May 2010
Developmental programming of EZH2 is a novel mechanism by which in utero exposure to endocrine disruptors leads to epigenetic regulation of the mammary gland.
Implantation failure: molecular mechanisms and clinical treatment.
This review summarizes the current knowledge about the proposed mechanisms of implantation failure in gynecological diseases, the evaluation of endometrial receptivity and the treatment methods to improve implantation.
HOX gene expression is altered in the endometrium of women with endometriosis.
Aberrant HOX gene expression suggests that altered development of the endometrium at the molecular level may contribute to the aetiology of infertility in patients with endometriosis.
A conserved Hox axis in the mouse and human female reproductive system: late establishment and persistent adult expression of the Hoxa cluster genes.
The pattern and timing of genes of the Hoxa axis in the development of the Müllerian tract are determined and it is shown that the late establishment of a Hox axis and persistent expression of Hox genes in the adult may play an important role in preserving this plasticity.
Endocrine regulation of HOX genes.
By regulating HOX genes, hormonal signals utilize a conserved mechanism that allows generation of structural and functional diversity in both developing and adult tissues.
Altered expression of HOXA10 in endometriosis: potential role in decidualization.
It is demonstrated that stromal cells from the eutopic endometrium of baboons with endometriosis expressed significantly higher levels of insulin-like growth factor binding protein-1 (IGFBP1) mRNA than disease-free animals in response to estradiol, medroxyprogesterone acetate and dibutyryl cAMP.
Arterial imaging outcomes and cardiovascular risk factors in recently menopausal women: a randomized trial.
Four years of early MHT did not affect progression of atherosclerosis despite improving some markers of CVD risk, and the likelihood of serious adverse events did not differ by treatment.
Experimental Murine Endometriosis Induces DNA Methylation and Altered Gene Expression in Eutopic Endometrium1
It is demonstrated that normal endometrium, when placed in an ectopic location to create experimental endometriosis, led to characteristic changes in gene expression in eutopic endometricrium, suggesting the existence of a signal conduction pathway from endometRIosis that alters endometrial gene expression through altered Pgr signaling and epigenetic programming.