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Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex.
Vertebrate Wnt proteins activate several distinct pathways. Intrinsic differences among Wnt ligands and Frizzled (Fzd) receptors, and the availability of pathway-specific coreceptors, LRP5/6, andExpand
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Evidence for different origin of sex chromosomes in snakes, birds, and mammals and step-wise differentiation of snake sex chromosomes
All snake species exhibit genetic sex determination with the ZZ/ZW type of sex chromosomes. To investigate the origin and evolution of snake sex chromosomes, we constructed, by FISH, a cytogeneticExpand
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  • Open Access
Planarian Hedgehog/Patched establishes anterior–posterior polarity by regulating Wnt signaling
Despite long-standing interest, the molecular mechanisms underlying the establishment of anterior–posterior (AP) polarity remain among the unsolved mysteries in metazoans. In the planarians (a familyExpand
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Progressive activation of Delta-Notch signaling from around the blastopore is required to set up a functional caudal lobe in the spider Achaearanea tepidariorum
In the development of most arthropods, the caudal region of the elongating germ band (the growth zone) sequentially produces new segments. Previous work with the spider Cupiennius salei suggestedExpand
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Etv2/ER71 induces vascular mesoderm from Flk1+PDGFRα+ primitive mesoderm.
Etv2 (Ets Variant 2) has been shown to be an indispensable gene for the development of hematopoietic cells (HPCs)/endothelial cells (ECs). However, how Etv2 specifies the mesoderm-generating HPCs/ECsExpand
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Travelling and splitting of a wave of hedgehog expression involved in spider-head segmentation
During development segmentation is a process that generates a spatial periodic pattern. Peak splitting of waves of gene expression is a mathematically predicted, simple strategy accounting for thisExpand
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The mRNA-like noncoding RNA Gomafu constitutes a novel nuclear domain in a subset of neurons
Recent transcriptome analyses have revealed that a large body of noncoding regions of mammalian genomes are actually transcribed into RNAs. Our understanding of the molecular features of theseExpand
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Highly conserved linkage homology between birds and turtles: Bird and turtle chromosomes are precise counterparts of each other
The karyotypes of birds, turtles and snakes are characterized by two distinct chromosomal components, macrochromosomes and microchromosomes. This close karyological relationship between birds andExpand
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Expression of stem cell pluripotency factors during regeneration in newts
In this study, we present data indicating that mammalian stem cell pluripotency‐inducing factors are expressed during lens and limb regeneration in newts. The apparent expression even in intactExpand
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A LIM-homeobox gene is required for differentiation of Wnt-expressing cells at the posterior end of the planarian body
Planarians have high regenerative ability, which is dependent on pluripotent adult somatic stem cells called neoblasts. Recently, canonical Wnt/β-catenin signaling was shown to be required forExpand
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