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Differential sensitivity of glioma- versus lung cancer-specific EGFR mutations to EGFR kinase inhibitors.
This work demonstrates selective sensitivity of glioma-specific EGFR mutants to ATP-site competitive EGFR kinase inhibitors that target the inactive conformation of the catalytic domain and provides first evidence for single kinase addiction in GBM. Expand
Requirement of HDAC6 for Transforming Growth Factor-β1-induced Epithelial-Mesenchymal Transition*
It is reported that HDAC6 is a novel modulator of TGF-β1-induced EMT and a potential therapeutic target against pathological EMT, a key event for tumor progression and fibrogenesis. Expand
Augmentation of NVP-BEZ235's anticancer activity against human lung cancer cells by blockage of autophagy
Induction of autophagy by BEZ235 appears to be a survival mechanism that may counteract its anticancer effects, and a strategy is suggested to enhance BEz235's anticancer efficacy by blockade ofAutophagy. Expand
Protein Phosphatase 2A and DNA-dependent Protein Kinase Are Involved in Mediating Rapamycin-induced Akt Phosphorylation*
PP2A-dependent and DNA-PK-mediated mechanism is involved in rapamycin-induced Akt phosphorylation and a novel strategy to enhance mTOR-targeted cancer therapy by co-targeting DNA- PK is suggested. Expand
The combination of RAD001 and NVP-BKM120 synergistically inhibits the growth of lung cancer in vitro and in vivo.
It is suggested that the combination of RAD001 and BKM120 may be an effective regimen for treatment of lung cancer, hence warranting further evaluation of the combination in the clinic. Expand
Acridine Yellow G Blocks Glioblastoma Growth via Dual Inhibition of Epidermal Growth Factor Receptor and Protein Kinase C Kinases*
  • Q. Qi, Kunyan He, +13 authors K. Ye
  • Medicine, Biology
  • The Journal of Biological Chemistry
  • 3 January 2012
Acridine yellow G is a potent anti-tumor agent for malignant gliomas and combinatorial inhibition of EGFR and PKCs might provide proof of concept in developing therapeutic agents for treating malignantglioma and other human cancers. Expand
c-Jun NH2-terminal kinase-dependent upregulation of DR5 mediates cooperative induction of apoptosis by perifosine and TRAIL
The combination of perifosine and TRAIL was more active than each single agent alone in inducing apoptosis of head and neck squamous cell carcinoma cells and inhibiting the growth of xenografts. Expand
Both genes and lncRNAs can be used as biomarkers of prostate cancer by using high throughput sequencing data.
The analysis used in this study is reliable in screening prostate cancer markers including both genes and lncRNAs by using RNA-seq data, which provides new insight into the understanding of molecular mechanism of prostate cancer. Expand
Sensitive, accurate and simple liquid chromatography-tandem mass spectrometric method for the quantitation of amphotericin B in human or minipig plasma.
A sensitive, accurate and simple liquid chromatography-tandem mass spectrometry method to quantify AMB in human or minipig plasma and has been validated and applied for AMB pharmacokinetic study in both human and minipigs plasma. Expand
Requirement of HDAC 6 for Transforming Growth Factor-1-induced Epithelial-Mesenchymal Transition *
The aberrant expression of transforming growth factor (TGF)1 in the tumor microenvironment and fibrotic lesions plays a critical role in tumor progression and tissue fibrosis by inducingExpand