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Vascularized and functional human liver from an iPSC-derived organ bud transplant
A critical shortage of donor organs for treating end-stage organ failure highlights the urgent need for generating organs from human induced pluripotent stem cells (iPSCs). Despite many reports… Expand
Side population purified from hepatocellular carcinoma cells harbors cancer stem cell–like properties
Recent advances in stem cell biology enable us to identify cancer stem cells in solid tumors as well as putative stem cells in normal solid organs. In this study, we applied side population (SP) cell… Expand
Renal L-type fatty acid--binding protein in acute ischemic injury.
- T. Yamamoto, E. Noiri, +12 authors T. Sugaya
- Journal of the American Society of Nephrology…
- 1 November 2007
Fatty acid-binding proteins (FABPs) bind unsaturated fatty acids and lipid peroxidation products during tissue injury from hypoxia. We evaluated the potential role of L-type FABP (L-FABP) as a… Expand
Multilineage communication regulates human liver bud development from pluripotency
Conventional two-dimensional differentiation from pluripotency fails to recapitulate cell interactions occurring during organogenesis. Three-dimensional organoids generate complex organ-like tissues;… Expand
Vascularized and Complex Organ Buds from Diverse Tissues via Mesenchymal Cell-Driven Condensation.
Transplantation of in-vitro-generated organ buds is a promising approach toward regenerating functional and vascularized organs. Though it has been recently shown in the context of liver models,… Expand
Clonal identification and characterization of self-renewing pluripotent stem cells in the developing liver
- A. Suzuki, Y. Zheng, +4 authors H. Taniguchi
- Biology, Medicine
- The Journal of cell biology
- 7 January 2002
Using flow cytometry and single cell–based assays, we prospectively identified hepatic stem cells with multilineage differentiation potential and self-renewing capability. These cells could be… Expand
Flow cytometric isolation and clonal identification of self‐renewing bipotent hepatic progenitor cells in adult mouse liver
The adult liver progenitor cells appear in response to several types of pathological liver injury, especially when hepatocyte replication is blocked. These cells are histologically identified as… Expand
The polycomb gene product BMI1 contributes to the maintenance of tumor-initiating side population cells in hepatocellular carcinoma.
Side population (SP) cell analysis and sorting have been successfully applied to hepatocellular carcinoma (HCC) cell lines to identify a minor cell population with cancer stem cell properties.… Expand
Usefulness of enhanced recovery after surgery protocol as compared with conventional perioperative care in gastric surgery
BackgroundRadical gastrectomy for gastric cancer is among the most invasive procedures in gastrointestinal surgery. Several studies have found that an enhanced recovery after surgery (ERAS) protocol… Expand
Production of Functional Spermatids from Mouse Germline Stem Cells in Ectopically Reconstituted Seminiferous Tubules1
- Kaoru Kita, T. Watanabe, +12 authors T. Ogawa
- Biology, Medicine
- Biology of reproduction
- 1 February 2007
Abstract Testicular germ cell transplantation into the seminiferous tubules is at present the only way to induce spermatogenesis from a given source of spermatogonial stem cells. Here we show an… Expand