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Inhibitory PAS Domain Protein (IPAS) Is a Hypoxia-inducible Splicing Variant of the Hypoxia-inducible Factor-3α Locus*
The inhibitory PAS (Per/Arnt/Sim) domain protein, IPAS, functions as a dominant negative regulator of hypoxia-inducible transcription factors (HIFs) by forming complexes with those proteins that failExpand
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Nuclear export of glucocorticoid receptor is enhanced by c-Jun N-terminal kinase-mediated phosphorylation.
The c-Jun N-terminal kinase (JNK) phosphorylates the glucocorticoid receptor (GR) and inhibits GR-mediated transcription. However, the biological effect of the GR phosphorylation remains unknown.Expand
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Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease
Blockade of mineralocorticoid receptor has been shown to improve the clinical outcomes of proteinuric kidney diseases. However, little is known about the regulation of mineralocorticoidExpand
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Spatial redox regulation of a critical cysteine residue of NF-kappa B in vivo.
Reduction-oxidation (redox) regulation has been implicated in the activation of the transcription factor NF-kappaB. However, the significance and mechanism of the redox regulation remain elusive,Expand
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High-performance affinity beads for identifying drug receptors
We have developed a method using novel latex beads for rapid identification of drug receptors using affinity purification. Composed of a glycidylmethacrylate (GMA) and styrene copolymer core with aExpand
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Spatial Redox Regulation of a Critical Cysteine Residue of NF-κB in Vivo *
Reduction-oxidation (redox) regulation has been implicated in the activation of the transcription factor NF-κB. However, the significance and mechanism of the redox regulation remain elusive, mainlyExpand
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Transcriptional Up-regulation of Inhibitory PAS Domain Protein Gene Expression by Hypoxia-inducible Factor 1 (HIF-1)
The inhibitory PAS (Per/Arnt/Sim) domain protein (IPAS), a dominant negative regulator of hypoxia-inducible transcription factors (HIFs), is potentially implicated in negative regulation ofExpand
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Aryl hydrocarbon receptor/dioxin receptor in human monocytes and macrophages
Aryl hydrocarbon receptor (AhR) belongs to the bHLH/PAS transcription factor family and is activated by various polycyclic or halogenated aromatic hydrocarbons, e.g., 2, 3, 7,Expand
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Induction of renoprotective gene expression by cobalt ameliorates ischemic injury of the kidney in rats.
Hypoxia in the tubulointerstitium has been thought to play pivotal roles in the pathophysiology of acute renal failure and the progression of chronic kidney disease. Pre-induction ofExpand
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Functional Interference of Sp1 and NF-κB through the Same DNA Binding Site
ABSTRACT Gene activation by NF-κB/Rel transcription factors is modulated by synergistic or antagonistic interactions with other promoter-bound transcription factors. For example, Sp1 sites are oftenExpand
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