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Age-predicted maximal heart rate revisited.
OBJECTIVES We sought to determine a generalized equation for predicting maximal heart rate (HRmax) in healthy adults. BACKGROUND The age-predicted HRmax equation (i.e., 220 - age) is commonly used… Expand
Aging, Habitual Exercise, and Dynamic Arterial Compliance
- H. Tanaka, F. Dinenno, K. Monahan, C. Clevenger, C. DeSouza, D. Seals
- 12 September 2000
BackgroundA reduction in compliance of the large-sized cardiothoracic (central) arteries is an independent risk factor for the development of cardiovascular disease with advancing age. Methods and… Expand
A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage
The p53 gene is frequently inactivated in human cancers. Here we have isolated a p53-inducible gene, p53R2, by using differential display to examine messenger RNAs in a cancer-derived human cell line… Expand
Regular Aerobic Exercise Prevents and Restores Age-Related Declines in Endothelium-Dependent Vasodilation in Healthy Men
BackgroundIn sedentary humans endothelium-dependent vasodilation is impaired with advancing age contributing to their increased cardiovascular risk, whereas endurance-trained adults demonstrate lower… Expand
Age and gender interactions in physiological functional capacity: insight from swimming performance.
One experimental approach to studying the effects of aging on physiological functional capacity in humans is to analyze the peak exercise performance of highly trained athletes with increasing age.… Expand
Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance
The transition from androgen-dependent to castration-resistant prostate cancer (CRPC) is a lethal event of uncertain molecular etiology. Comparing gene expression in isogenic androgen-dependent and… Expand
Absence of age-related increase in central arterial stiffness in physically active women.
Increased arterial stiffness is thought to contribute to the increased incidence of cardiovascular disease with age. Little, however, is known about the influence of aging on central and peripheral… Expand
Central Arterial Compliance Is Associated With Age- and Habitual Exercise–Related Differences in Cardiovagal Baroreflex Sensitivity
Background—Cardiovagal baroreflex sensitivity (BRS) declines with age but is favorably modulated by habitual aerobic exercise. We tested the hypothesis that compliance (transducing capacity) of an… Expand
Clinical Significance of Osteoprotegerin Expression in Human Colorectal Cancer
Purpose: This study aimed to identify a novel biomarker or a target of treatment for colorectal cancer (CRC). Experimental Design: The expression profiles of cancer cells in 104 patients with CRC… Expand
Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth.
Oxidative and electrophilic stresses are sensed by Keap1, which activates Nrf2 to achieve cytoprotection by regulating the expression of drug-metabolizing and antioxidative stress enzymes/proteins.… Expand