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Differential production of MCP‐1 and cytokine‐induced neutrophil chemoattractant in the ischemic brain after transient focal ischemia in rats
TLDR
It is suggested that MCP‐1 in cerebral ischemia actually plays a significant role in the migration of macrophages into the lesion and that the differential temporal production of these chemokines contributes to the regulation of infiltrated leukocyte subtypes.
Comparison of hemorrhagic effect of heparin and human activated protein C with use of Thrombostat 4000.
TLDR
APC may be a more useful anticoagulant than heparin since it causes less bleeding tendency, and this study compared the bleeding complication of intravenously administered APC andHeparin in rabbits, and also estimated primary hemostasis.
Elevation of tail skin temperature in ovariectomized rats in relation to menopausal hot flushes.
TLDR
Results demonstrated that the elevation of TST in OVX rats was exhibited soon after the estrogen removal and diminished with time and that it was normalized with continuous E(2) replacement, which is similar to the symptoms of menopausal HFs in women.
Neuroprotective effect of TTC-909, an isocarbacyclin methyl ester incorporated in lipid microspheres, on hippocampal delayed neuronal death of stroke-prone spontaneously hypertensive rats.
TLDR
TTC-909, given intravenously 10 min after the transient forebrain ischemia, dose-dependently protected against ischemic delayed neuronal death in the hippocampus and the blood pressure remained unchanged following TTC-909 administration.
Antihypertensive effect of the new dihydropyridine calcium antagonist (+-)-3-(benzylmethylamino)-2,2-dimethylpropyl methyl 4-(2-fluoro-5-nitrophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedica rbo
TLDR
From these observations, TC-81 can be characterized as having a strong, long-lasting, and slow-onset antihypertensive activity, especially by oral administration, therefore, this new calcium antagonist may be useful for long-term anti Hypertensive therapy.
Effect of isocarbacyclin methyl ester incorporated in lipid microspheres on experimental models of peripheral obstructive disease.
TLDR
It is suggested that TTC-909 may be clinically useful for the therapy of peripheral vascular disorders such as thromboangiitis obliteran (TAO) and atherosclerosis obliterans (ASO).
Binding affinities of isocarbacyclin methyl ester and its free acid to prostanoid receptors.
TLDR
The binding affinities of isocarbacyclin methyl ester and its free acid to prostaglandin (PG) I2 receptors, PGE2 receptors (EP receptors) and thromboxane A 2 receptors (TP receptors) were investigated to suggest that TEI-9090 is converted to TEI -7165 by esterase, and thatTEI-7165 exerts pharmacological effects through binding to IP receptors.
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