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Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats.
- A. Okuno, H. Tamemoto, +9 authors T. Kadowaki
- The Journal of clinical investigation
- 15 March 1998
Troglitazone (CS-045) is one of the thiazolidinediones that activate the peroxisome proliferator-activated receptor gamma (PPARgamma), which is expressed primarily in adipose tissues. To elucidate… Expand
Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone
When growth hormone binds to its receptor, which belongs to the cytokine receptor superfamily, it activates the Janus kinase Jak2 which has tyrosine-kinase activity and initiates an activation of… Expand
A novel negative selection for homologous recombinants using diphtheria toxin A fragment gene.
In producing mutant mice by gene targeting in embryonic stem (ES) cells, the efficient isolation of the homologous recombinants is still a critical step. We previously reported on a negative… Expand
Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1
INSULIN receptor substrate-1 (IRS-1) is the major substrate of insulin receptor and IGF-1 receptor tyrosine kinases; it has an apparent relative molecular mass of 160190,000 (Mr, 160190K) on SDS… Expand
Parthenogenetic activation of oocytes in c-mos-deficient mice
Nature 370, 68-71 (1994) FIGURE 3b and c of this Letter was an early version that should not have been published. The correct version of this figure is shown here.
PPARγ Mediates High-Fat Diet–Induced Adipocyte Hypertrophy and Insulin Resistance
Abstract Agonist-induced activation of peroxisome proliferator-activated receptor γ (PPARγ) is known to cause adipocyte differentiation and insulin sensitivity. The biological role of PPARγ was… Expand
PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance.
Agonist-induced activation of peroxisome proliferator-activated receptor gamma (PPAR gamma) is known to cause adipocyte differentiation and insulin sensitivity. The biological role of PPAR gamma was… Expand
Mechanical loading activates mitogen-activated protein kinase and S6 peptide kinase in cultured rat cardiac myocytes.
- T. Yamazaki, K. Tobe, +7 authors Y. Yazaki
- Biology, Medicine
- The Journal of biological chemistry
- 5 June 1993
The molecular mechanisms by which overloaded cardiac myocytes increase the cell size (hypertrophy) remain unknown. We have previously shown that mechanical loading increased the protein synthesis and… Expand
Signal transduction mechanism of insulin and insulin-like growth factor-1.
Insulin and insulin-like growth factor-1 (IGF-1) are two structurally related hormones which produce similar biological activities such as metabolic and growth promoting actions. Their receptors,… Expand
Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice.
- T. Yamauchi, K. Tobe, +10 authors T. Kadowaki
- Biology, Medicine
- Molecular and cellular biology
- 1 June 1996
We and others recently generated mice with a targeted disruption of the insulin receptor substrate 1 (IRS-1) gene and demonstrated that they exhibited growth retardation and had resistance to the… Expand