Mutations and common polymorphisms in ADAMTS13 gene responsible for von Willebrand factor-cleaving protease activity
- K. Kokame, M. Matsumoto, Y. Fujimura
- BiologyProceedings of the National Academy of Sciences…
- 14 August 2002
A single-nucleotide polymorphism associated with alterations in VWF-CP activity is reported and it will be important to assess this single- nucleotide SNP as a risk factor for thrombotic disorders.
Vitamin E decreases bone mass by stimulating osteoclast fusion
It is shown that mice deficient in α-tocopherol transfer protein (Ttpa−/− mice), a mouse model of genetic vitamin E deficiency, have high bone mass as a result of a decrease in bone resorption, and serum vitamin E is a determinant of bone mass through its regulation of osteoclast fusion.
Free-radical chain oxidation of rat red blood cells by molecular oxygen and its inhibition by alpha-tocopherol.
Raised concentrations of aldehyde lipid peroxidation products in premature infants with chronic lung disease
- T. Ogihara, Kazuya Hirano, H. Tamai
- Medicine, ChemistryArchives of Disease in Childhood: Fetal and…
- 1 January 1999
AIM To indicate the extent of lipid peroxidation induced by oxidative stress, by measuring aldehyde end products in biological samples. METHODS A highly specific gas chromatography and mass…
Effects of neutrophil-derived oxidants on intestinal permeability, electrolyte transport, and epithelial cell viability
- M. Grisham, T. Gaginella, C. Ritter, H. Tamai, R. Be, D. Granger
- Medicine, BiologyInflammation
- 1 October 1990
The data suggest that PMN-derived oxidants may mediate the enhanced mucosal permeability, electrolyte transport, and epithelial cell injury associated with acute inflammation of the bowel.
Parietal dysfunction in developmental coordination disorder: a functional MRI study
- M. Kashiwagi, S. Iwaki, Y. Narumi, H. Tamai, Shuhei Suzuki
- Psychology, MedicineNeuroReport
- 7 October 2009
The comparison of the activation maps showed that the brain activity in the left posterior parietal cortex and left postcentral gyrus was lower in the DCD children than in the control children, suggesting that the dysfunction of these regions may be the neural underpinnings of impaired motor skill in DCDChildren.
Faecal chitinase 3‐like‐1: a novel biomarker of disease activity in paediatric inflammatory bowel disease
Aliment Pharmacol Ther 2011; 34: 941–948
Functional analysis of PTPN11/SHP-2 mutants identified in Noonan syndrome and childhood leukemia
The results suggest that the pathogenesis of NS and leukemia is associated with enhanced phosphatase activity of mutant SHP-2, and high phosphat enzyme activity observed in mutations at codons 61, 71, 72, and 76 was significantly associated with leukemogenesis.
Greater Oxidative Stress in Healthy Young Men Compared With Premenopausal Women
- T. Ide, H. Tsutsui, A. Takeshita
- MedicineArteriosclerosis, Thrombosis and Vascular Biology
- 1 March 2002
Abstract—Coronary risk factors, including age, hypertension, diabetes mellitus, hyperlipidemia, and smoking, are associated with enhanced oxidative stress, which is implicated as a potential…