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The FOXE1 locus is a major genetic determinant for radiation-related thyroid carcinoma in Chernobyl.
Papillary thyroid cancer (PTC) among individuals exposed to radioactive iodine in their childhood or adolescence is a major internationally recognized health consequence of the Chernobyl accident. ToExpand
Thiazolidinediones partially reverse the metabolic disturbances observed in Bscl2/seipin-deficient mice
Aims/hypothesisMutations in BSCL2/seipin cause Berardinelli–Seip congenital lipodystrophy (BSCL), a rare recessive disorder characterised by near absence of adipose tissue and severe insulinExpand
Integrating perfusable vascular networks with a three-dimensional tissue in a microfluidic device.
Creating vascular networks in tissues is crucial for tissue engineering. Although recent studies have demonstrated the formation of vessel-like structures in a tissue model, long-term culture isExpand
Stimulation of Glucose Uptake in Muscle Cells by Prolonged Treatment with Scriptide, a Histone Deacetylase Inhibitor
Glucose incorporation is regulated mainly by GLUT4 in skeletal muscles. Here we report that treatment of L6 myotubes with scriptide, a hydroxamic acid-based histone deacetylase (HDAC) inhibitor,Expand
Modulation of apical constriction by Wnt signaling is required for lung epithelial shape transition
In lung development, the apically constricted columnar epithelium forms numerous buds during the pseudoglandular stage. Subsequently, these epithelial cells change shape into the flat or cuboidalExpand
PtdIns(3,5)P2 mediates root hair shank hardening in Arabidopsis
Root hairs elongate by tip growth and simultaneously harden the shank by constructing the inner secondary cell wall layer. While much is known about the process of tip growth1, almost nothing isExpand
A Theoretical Model of Jigsaw-Puzzle Pattern Formation by Plant Leaf Epidermal Cells
We propose a simple interface equation model that incorporates both the cell wall remodeling activity of ROP GTPases and diffusible signaling molecules by which they are regulated. Expand
Transcriptional autoregulation by phosphorylated and non-phosphorylated KaiC in cyanobacterial circadian rhythms.
Cyanobacteria are the simplest organisms known to exhibit circadian rhythms, which is the fundamental process of homeostasis adapting to daily environmental changes. The cyanobacterial clock geneExpand
Predicting Regulation of the Phosphorylation Cycle of KaiC Clock Protein Using Mathematical Analysis
Abstract The cyanobacterial clock protein KaiC regulates the circadian cycle by exhibiting rhythms in transcription, translation, and phosphorylation. KaiC phosphorylation persists in circadianExpand
Exogenous Cellulase Switches Cell Interdigitation to Cell Elongation in an RIC1-dependent Manner in Arabidopsis thaliana Cotyledon Pavement Cells
Pavement cells in cotyledons and true leaves exhibit a jigsaw puzzle-like morphology in most dicotyledonous plants. Among the molecular mechanisms mediating cell morphogenesis, two antagonisticExpand