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Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts.
Signaling by RANKL is essential for terminal differentiation of monocytes/macrophages into osteoclasts. The TRAF6 and c-Fos signaling pathways both play important roles downstream of RANKL. We showExpand
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Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems
  • H. Takayanagi
  • Medicine, Biology
  • Nature Reviews Immunology
  • 1 April 2007
Osteoimmunology is an interdisciplinary research field focused on the molecular understanding of the interplay between the immune and skeletal systems. Although osteoimmunology started with the studyExpand
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The molecular understanding of osteoclast differentiation.
Osteoclasts are multinucleated cells of monocyte/macrophage origin that degrade bone matrix. The differentiation of osteoclasts is dependent on a tumor necrosis factor (TNF) family cytokine, receptorExpand
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Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis
Costimulatory signals are required for activation of immune cells, but it is not known whether they contribute to other biological systems. The development and homeostasis of the skeletal systemExpand
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Evidence for osteocyte regulation of bone homeostasis through RANKL expression
Osteocytes embedded in bone have been postulated to orchestrate bone homeostasis by regulating both bone-forming osteoblasts and bone-resorbing osteoclasts. We find here that purified osteocytesExpand
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RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-β
Osteoclasts are cells of monocyte/macrophage origin that erode bone matrix: regulation of their differentiation is central to the understanding of the pathogenesis and treatment of bone diseases suchExpand
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Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction
In autoimmune arthritis, traditionally classified as a T helper (Th) type 1 disease, the activation of T cells results in bone destruction mediated by osteoclasts, but how T cells enhanceExpand
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Autoamplification of NFATc1 expression determines its essential role in bone homeostasis
NFATc1 and NFATc2 are functionally redundant in the immune system, but it was suggested that NFATc1 is required exclusively for differentiation of osteoclasts in the skeletal system. Here we provideExpand
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Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction
Sato et al. 2006. J. Exp. Med. doi:10.1084/jem.20061775[OpenUrl][1][Abstract/FREE Full Text][2] [1]:Expand
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The role of NFAT in osteoclast formation.
  • H. Takayanagi
  • Medicine, Biology
  • Annals of the New York Academy of Sciences
  • 1 November 2007
Osteoclasts are cells of monocyte-macrophage origin that degrade bone matrix. Receptor activator of NF-kappaB ligand (RANKL) induces osteoclast formation in the presence ofExpand
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