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Nitric oxide as a bioregulator of apoptosis.
The antiapoptotic mechanism can be understood via expression of protective genes such as heat shock proteins, Bcl-2 as well as direct inhibition of the apoptotic caspase family proteases by S-nitrosylation of the cysteine thiol. Expand
Differential regulation of NO availability from macrophages and endothelial cells by the garlic component S-allyl cysteine.
It is demonstrated that garlic extract and SAC, due to their antioxidant activity, differentially regulate NO production by inhibiting iNOS expression in macrophages while increasing NO in endothelial cells, which may contribute to the anti-inflammatory effect and prevention of atherosclerosis by these reagents. Expand
Overexpression of protein kinase C isoforms protects RAW 264.7 macrophages from nitric oxide-induced apoptosis: involvement of c-Jun N-terminal kinase/stress-activated protein kinase, p38 kinase, and
It is concluded that PKC protects NO-induced apoptotic cell death, presumably nullifying the NO-mediated activation of JNK/SAPK, p38 kinase, and CPP32-like protease in RAW 264.7 parent cells. Expand
Dopamine D2 receptor dimers and receptor-blocking peptides.
Dopamine D2 receptors exist as dimers in whole cell lysate, crude membranes prepared from human caudate, and following solubilization and immunoprecipitation of the receptor from these tissues.Expand
Activation of c-Jun N-terminal kinase 1 (JNK1) in mistletoe lectin II-induced apoptosis of human myeloleukemic U937 cells.
Among the three components, lectin II was the most potent in inducing apoptosis as well as JNK1 activation of U937 cells in a dose- and time-dependent manner. Expand
Nitric oxide inhibits c-Jun N-terminal kinase 2 (JNK2) via S-nitrosylation.
The results indicate that NO may exert a regulatory role of JNK2 activity by S-nitrosylation of the protein in apoptotic signaling pathway, supported by the observation that NO plays an important anti-apoptotic roles in heptocytes, splenocytes, eosinophils and B lymphocytes. Expand
Qi therapy as an intervention to reduce chronic pain and to enhance mood in elderly subjects: a pilot study.
There was a significant reduction in pain after QT and an improved positive mood state and these findings suggest that Qi therapy may have a role in helping the elderly to cope with their pain and mood disturbances. Expand
Recombinant interferon-alpha in inoperable hepatocellular carcinoma: a randomized controlled trial.
It is concluded that interferon-alpha is useful in a proportion of Chinese patients with inoperable hepatocellular carcinoma, both in prolonging survival and in inducing tumor regression. Expand
Involvement of prostaglandins in the immune alterations caused by the exposure of mice to ultraviolet radiation.
High-dose UVR-exposed animals, which normally exhibit a depression in responsiveness to hapten sensitization, retained a normal capacity to elicit CH responses if treated with the drug indomethacin, implicate prostaglandins in the pathogenesis of the immunologic hyporesponsiveness. Expand
Pathogenic role of hepatitis B virus in hepatitis B surface antigen-negative decompensated cirrhosis.
It is found that using PCR, serum HBV DNA can be detected in 28% of HBsAg-negative cirrhotic patients who were studied, but the pathogenic significance of such small amounts of virus is not clear. Expand