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In vivo evaluation of the biodistribution and safety of PLGA nanoparticles as drug delivery systems.
UNLABELLED The remarkable physicochemical properties of particles in the nanometer range have been proven to address many challenges in the field of science. However, the possible toxic effects ofExpand
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A polymeric system for the intra-oral delivery of an anti-fungal agent.
Oral candidal infections are often persistent and intractable and thus the aim of this study was to develop a polymeric sustained release device to improve the topical treatment of these infections.Expand
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Effects of protein binding on the biodistribution of PEGylated PLGA nanoparticles post oral administration.
The surface of nanoparticles is often functionalised with polymeric surfactants, in order to increase systemic circulation time. This has been investigated mainly for intravenously administeredExpand
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Development, characterization and antimalarial efficacy of dihydroartemisinin loaded solid lipid nanoparticles.
UNLABELLED Effective use of dihydroartemisinin (DHA) is limited by poor water-solubility, poor pharmacokinetic profile and unsatisfactory clinical outcome especially in monotherapy. To reduce suchExpand
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In vivo uptake and acute immune response to orally administered chitosan and PEG coated PLGA nanoparticles.
Nanoparticulate drug delivery systems offer great promise in addressing challenges of drug toxicity, poor bioavailability and non-specificity for a number of drugs. Much progress has been reportedExpand
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Enhancing adherence to antiretroviral therapy at the HIV clinic in resource constrained countries; the Tanzanian experience
Objective  To evaluate various strategies aimed at improving adherence to antiretroviral therapy (ART).
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Nanomedicine: Past, present and future - A global perspective.
Nanomedicine is an emerging and rapidly evolving field and includes the use of nanoparticles for diagnosis and therapy of a variety of diseases, as well as in regenerative medicine. In thisExpand
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Enhanced oral bioavailability of the antiretroviral efavirenz encapsulated in poly(epsilon-caprolactone) nanoparticles by a spray-drying method.
AIM To encapsulate efavirenz (EFV) within poly(epsilon-caprolactone) (PCL) nanoparticles (NPs) and compare the oral pharmacokinetics with that of EFV-loaded micelles and pure EFV NPs. MATERIALS &Expand
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Curdlan-Conjugated PLGA Nanoparticles Possess Macrophage Stimulant Activity and Drug Delivery Capabilities
PurposeThere is significant interest in the application of nanoparticles to deliver immunostimulatory signals to cells. We hypothesized that curdlan (immune stimulating polymer) could be conjugatedExpand
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Antimicrobial packaging based on starch, poly(3-hydroxybutyrate) and poly(lactic-co-glycolide) materials and application challenges
Abstract Background In recent years, food packaging has focused on two scientific pillars; adopting the biodegradable packaging materials and development of antimicrobial packaging for extended shelfExpand
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