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Double blockade of cell cycle progression by coptisine in vascular smooth muscle cells.
It is demonstrated that a small difference in the structure between isoquinoline alkaloids produces a big difference in activity, and that coptisine has a unique double action in arresting the cell cycle of VSMCs. Expand
Antihypertensive actions of methylripariochromene A from Orthosiphon aristatus, an Indonesian traditional medicinal plant.
It is presumed that the traditional use of this plant in the therapy of hypertension may be partially supported by these actions related to antihypertensive activity with MRC, i.e. vasodilating action, a decrease in cardiac output and diuretic action. Expand
Screening of natural compounds for inhibitory activity on colon cancer cell migration.
Results suggest that evodiamine and paclitaxel may be regarded as leading compounds for anti-metastatic agents acting through the inhibition of tumor cell migration without cytotoxicity. Expand
Selective inhibition of vascular smooth muscle cell proliferation by coptisine isolated from Coptis rhizoma, one of the crude drugs composing Kampo medicines Unsei-in.
Evidence is provided that coptisine, an ingredient of Unsei-in, prevents VSMC proliferation selectively at lower concentrations compared with various cells or other structurally related alkaloids. Expand
The safety of a mucosal vaccine using the C-terminal fragment of Clostridium perfringens enterotoxin.
Findings indicate that claudin-4-targeting using C-CPE can be a potent strategy for mucosal vaccination. Expand
Taurine as a protective agent for 5-fluorouracil-induced hepatic damage related to oxidative stress.
It is suggested that taurine protects against 5-FU-induced hepatotoxicity by suppressing oxidative stress. Expand
Costunolide and dehydrocostus lactone as inhibitors of killing function of cytotoxic T lymphocytes.
The results suggest that costunolide inhibits the killing activity of CTL through preventing the increase in tyrosine phosphorylation in response to the crosslinking of T-cell receptors. Expand
Clinical consequences of 2'-deoxycoformycin treatment in patients with refractory adult T-cell leukaemia.
Five patients from the Kyushu area in Japan with adult T-cell leukaemia (ATL) refractory to conventional chemotherapeutic agents were treated with 5 mg/m2 of the adenosine deaminase inhibitor,Expand
Inhibitory effects of evodiamine on in vitro invasion and experimental lung metastasis of murine colon cancer cells.
The results suggest that evodiamine may be regarded as a promising agent in tumor metastasis therapy, whereas cisplatin caused serious weight loss in mice in the experimental period. Expand
Reversal of P-glycoprotein and multidrug-resistance protein-mediated drug resistance in KB cells by 5-O-benzoylated taxinine K.
A newly synthesized taxoid originally from the Japanese yew Taxus cuspidata, 5-O-benzoylated taxinine K (BTK) was examined for its ability to reverse P-glycoprotein (P-gp) and multidrug resistanceExpand