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Molecular cloning and functional analysis of a cDNA coding for human DOPAchrome tautomerase/tyrosinase-related protein-2.
We have cloned the cDNAs encoding tyrosinase-related protein-2 (TRP-2) from a human melanoma cDNA library. Transient expression of the isolated cDNA in HeLa cells established that TRP-2 is DOPAchromeExpand
Expression of heme oxygenase and inducible nitric oxide synthase mRNA in human brain tumors.
Heme oxygenase-1, a key enzyme in heme catabolism, and inducible nitric oxide synthase (iNOS) are responsible for production of carbon monoxide and nitric oxide (NO), respectively. Expression of eachExpand
Cloning of the human DOPAchrome tautomerase/tyrosinase-related protein 2 gene and identification of two regulatory regions required for its pigment cell-specific expression.
We have cloned and sequenced the human genomic DNA segments encoding the 5'-flanking region and the first two exons of the DOPAchrome tautomerase (DT)/tyrosinase-related protein 2 (TRP-2) gene. TheExpand
Transcriptional activation of the melanocyte-specific genes by the human homolog of the mouse Microphthalmia protein.
Mi protein encoded at the mouse microphthalmia (mi) locus is a transcription factor with a basic helix-loop-helix/leucine zipper structure. To assess the function of the human homolog of Mi protein,Expand
Structure and function of human histamine N-methyltransferase: critical enzyme in histamine metabolism in airway.
In mammals, histamine is inactivated principally by two enzymes: histamine N-methyltransferase (HMT; EC and diamine oxidase (DAO; EC The cDNA clone of human HMT (hHMT) has beenExpand
Identification of a melanocyte-type promoter of the microphthalmia-associated transcription factor gene.
Microphthalmia-associated transcription factor (MITF), the human homolog of the mouse microphthalmia gene product, regulates melanocyte-specific transcription of the tyrosinase gene that codes for anExpand
Expression of Heme Oxygenase Isozyme mRNAs in the Human Brain and Induction of Heme Oxygenase‐1 by Nitric Oxide Donors
Abstract: Heme oxygenase is an essential enzyme in the heme catabolism that produces carbon monoxide (CO). This study was designed to examine the expression of two heme oxygenase isozyme mRNAs in theExpand
Melanin-concentrating hormone in human and rat.
Melanin-concentrating hormone (MCH) is a neuropeptide originally isolated from chum salmon pituitaries. To explore physiological roles of MCH in mammals, we studied the regional distribution ofExpand
Re-evaluation of exercise prescription for Japanese type 2 diabetic patients by ventilatory threshold.
Prescription of aerobic exercise for Type 2 diabetes mellitus (Type 2 DM) in clinical practice is frequently based on exercise intensity at maximum heart rate (60<HR(max)<79%), heart rate reserveExpand
Changes in serum leptin concentrations in overweight Japanese men after exercise
Aim:  To investigate the link between serum leptin concentrations and exercise.