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Effects of Suvorexant, an Orexin Receptor Antagonist, on Respiration during Sleep In Patients with Obstructive Sleep Apnea.
- H. Sun, J. Palcza, +6 authors M. Troyer
- Journal of clinical sleep medicine : JCSM…
- 15 January 2016
STUDY OBJECTIVES To investigate the respiratory effects of suvorexant, an orexin receptor antagonist for treating insomnia, in patients with obstructive sleep apnea (OSA). METHODS This was a… Expand
Effects of suvorexant, an orexin receptor antagonist, on sleep parameters as measured by polysomnography in healthy men.
STUDY OBJECTIVES Suvorexant (MK-4305) is an orexin receptor antagonist being developed for the treatment of insomnia. This report describes the effects of nighttime administration of suvorexant on… Expand
Invasive fungal infections among inpatients with acquired immune deficiency syndrome at a Chinese university hospital
Invasive fungal infections (IFIs) have become a major cause of morbidity and mortality among people with acquired immune deficiency syndrome (AIDS), however, little is known about the clinical… Expand
On-the-Road Driving Performance the Morning after Bedtime Use of Suvorexant 20 and 40 mg: A Study in Non-Elderly Healthy Volunteers.
STUDY OBJECTIVE To evaluate next-morning driving performance in adults younger than 65 years, after single and repeated doses of suvorexant 20 and 40 mg. DESIGN Double-blind, placebo-controlled,… Expand
Effects of supplementing sow diets during two gestations with konjac flour and Saccharomyces boulardii on constipation in peripartal period, lactation feed intake and piglet performance
Abstract This study investigated the effects of supplementation of konjac flour (KF) and Saccharomyces boulardii (SB) either alone or in combination to sow gestation diets over two successive… Expand
Effects of lysine and protein intake over two consecutive lactations on lactation and subsequent reproductive performance in multiparous sows
Abstract The aim of the study was to evaluate that the effect of lysine and protein intake over two consecutive lactations on lactation and subsequent reproductive performance in multiparous sows.… Expand
Effects of the orexin receptor antagonist suvorexant on respiration during sleep in healthy subjects
Suvorexant is an orexin receptor antagonist for treating insomnia. The maximum approved dose in the United States and Japan is 20 mg. We evaluated suvorexant effects on respiration during sleep in a… Expand
On-the-road driving performance the morning after bedtime use of suvorexant 15 and 30 mg in healthy elderly
RationaleSuvorexant is a first-in-class orexin receptor antagonist for treating insomnia. There is a general concern that hypnotics may impair next-morning driving ability.ObjectiveThe objective of… Expand
Psychomotor effects, pharmacokinetics and safety of the orexin receptor antagonist suvorexant administered in combination with alcohol in healthy subjects
- H. Sun, K. Yee, +8 authors M. Troyer
- Psychology, Medicine
- Journal of psychopharmacology
- 13 October 2015
A double-blind crossover study investigated psychomotor effects, pharmacokinetics, and safety of the orexin receptor antagonist suvorexant with and without alcohol. Healthy adults (n=31) were… Expand
Assessment of the Abuse Potential of the Orexin Receptor Antagonist, Suvorexant, Compared With Zolpidem in a Randomized Crossover Study
- K. Schoedel, H. Sun, +12 authors J. Wagner
- Journal of clinical psychopharmacology
- 1 August 2016
Abstract Suvorexant is a dual orexin receptor antagonist approved in the United States and Japan for the treatment of insomnia at a maximum dose of 20 mg. This randomized double-blind crossover study… Expand