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Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells.
Lymphomas arising from NK or γδ-T cells are very aggressive diseases and little is known regarding their pathogenesis. Here we report frequent activating mutations of STAT3 and STAT5B in NK/T-cell… Expand
Double-strand breaks at an initiation site for meiotic gene conversion
IT has been proposed that the initiation of meiotic recombination involves either single-strand or double-strand breaks in DNA1–3. It is difficult to distinguish between these on the basis of genetic… Expand
Arsenite alters global histone H3 methylation.
Arsenic (As) is a well-characterized human carcinogen but is generally not mutagenic. The evidence that As induces both loss of global DNA methylation and gene promoter DNA hypermethylation has… Expand
Safety and efficacy of AMG 334 for prevention of episodic migraine: a randomised, double-blind, placebo-controlled, phase 2 trial
BACKGROUND The calcitonin gene-related peptide (CGRP) pathway is a promising target for preventive therapies in patients with migraine. We assessed the safety and efficacy of AMG 334, a fully human… Expand
Modulation of histone methylation and MLH1 gene silencing by hexavalent chromium.
- H. Sun, X. Zhou, Hao-bin Chen, Q. Li, Max Costa
- Biology, Medicine
- Toxicology and applied pharmacology
- 15 June 2009
Hexavalent chromium [Cr(VI)] is a mutagen and carcinogen, and occupational exposure can lead to lung cancers and other adverse health effects. Genetic changes resulting from DNA damage have been… Expand
LSD1 Regulates Pluripotency of Embryonic Stem/Carcinoma Cells through Histone Deacetylase 1-Mediated Deacetylation of Histone H4 at Lysine 16
- F. Yin, Rongfeng Lan, +8 authors H. Zhang
- Biology, Medicine
- Molecular and Cellular Biology
- 4 November 2013
ABSTRACT LSD1 is essential for the maintenance of pluripotency of embryonic stem (ES) or embryonic carcinoma/teratocarcinoma (EC) cells. We have previously developed novel LSD1 inhibitors that… Expand
Peroxisome proliferator-activated receptor gamma agonist, rosiglitazone, suppresses CD40 expression and attenuates inflammatory responses after lithium pilocarpine-induced status epilepticus in rats
- H. Sun, Yuangui Huang, X. Yu, Y. Li, Gang Zhao
- International Journal of Developmental…
- 1 August 2008
Inflammatory responses in the brain are involved in the etiopathogenesis and sequelae of seizures. Ligation of microglial CD40 plays a role in the development of inflammatory responses in the central… Expand
Activating mutations of STAT5B and STAT3 in lymphomas derived from gamma delta-T or NK cells
Kucuk , C , Jiang , B , Hu , X , Zhang , W , Chan , J K C , Xiao , W , Lack , N , Alkan , C , Williams , J C , Avery , K N , Kavak , P , Scuto , A , Sen , E , Gaulard , P , Staudt , L , Iqbal , J ,… Expand
Essential oil composition, antimicrobial and antioxidant properties of Mosla chinensis Maxim
Abstract The essential oil of Mosla chinensis Maxim was analysed by gas chromatography/mass spectrometry, and its main components are carvacrol (57.08%), p -cymene (13.61%), thymol acetate (12.68%),… Expand
Effects of suvorexant, an orexin receptor antagonist, on breathing during sleep in patients with chronic obstructive pulmonary disease.
OBJECTIVES There is a general concern that hypnotic medications in patients with respiratory disorders have the potential to decrease respiratory effort and blunt the arousal response to hypoxemia… Expand