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Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells.
Lymphomas arising from NK or γδ-T cells are very aggressive diseases and little is known regarding their pathogenesis. Here we report frequent activating mutations of STAT3 and STAT5B in NK/T-cellExpand
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Double-strand breaks at an initiation site for meiotic gene conversion
IT has been proposed that the initiation of meiotic recombination involves either single-strand or double-strand breaks in DNA1–3. It is difficult to distinguish between these on the basis of geneticExpand
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Arsenite alters global histone H3 methylation.
Arsenic (As) is a well-characterized human carcinogen but is generally not mutagenic. The evidence that As induces both loss of global DNA methylation and gene promoter DNA hypermethylation hasExpand
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Safety and efficacy of AMG 334 for prevention of episodic migraine: a randomised, double-blind, placebo-controlled, phase 2 trial
BACKGROUND The calcitonin gene-related peptide (CGRP) pathway is a promising target for preventive therapies in patients with migraine. We assessed the safety and efficacy of AMG 334, a fully humanExpand
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Modulation of histone methylation and MLH1 gene silencing by hexavalent chromium.
Hexavalent chromium [Cr(VI)] is a mutagen and carcinogen, and occupational exposure can lead to lung cancers and other adverse health effects. Genetic changes resulting from DNA damage have beenExpand
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LSD1 Regulates Pluripotency of Embryonic Stem/Carcinoma Cells through Histone Deacetylase 1-Mediated Deacetylation of Histone H4 at Lysine 16
ABSTRACT LSD1 is essential for the maintenance of pluripotency of embryonic stem (ES) or embryonic carcinoma/teratocarcinoma (EC) cells. We have previously developed novel LSD1 inhibitors thatExpand
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Peroxisome proliferator-activated receptor gamma agonist, rosiglitazone, suppresses CD40 expression and attenuates inflammatory responses after lithium pilocarpine-induced status epilepticus in rats
Inflammatory responses in the brain are involved in the etiopathogenesis and sequelae of seizures. Ligation of microglial CD40 plays a role in the development of inflammatory responses in the centralExpand
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Activating mutations of STAT5B and STAT3 in lymphomas derived from gamma delta-T or NK cells
Kucuk , C , Jiang , B , Hu , X , Zhang , W , Chan , J K C , Xiao , W , Lack , N , Alkan , C , Williams , J C , Avery , K N , Kavak , P , Scuto , A , Sen , E , Gaulard , P , Staudt , L , Iqbal , J ,Expand
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Essential oil composition, antimicrobial and antioxidant properties of Mosla chinensis Maxim
Abstract The essential oil of Mosla chinensis Maxim was analysed by gas chromatography/mass spectrometry, and its main components are carvacrol (57.08%), p -cymene (13.61%), thymol acetate (12.68%),Expand
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Effects of suvorexant, an orexin receptor antagonist, on breathing during sleep in patients with chronic obstructive pulmonary disease.
OBJECTIVES There is a general concern that hypnotic medications in patients with respiratory disorders have the potential to decrease respiratory effort and blunt the arousal response to hypoxemiaExpand
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