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Efficacy of and Patient Compliance with a Ketogenic Diet in Adults with Intractable Epilepsy: A Meta-Analysis
The results indicate that aketogenic diet is a promising complementary therapy in adult intractable epilepsy, and that while a classical ketogenic diet may be more effective, adult patients are likely to be less compliant with it than with a modified Atkins diet. Expand
Neutrophil-mediated anticancer drug delivery for suppression of postoperative malignant glioma recurrence.
It is shown that NEs carrying liposomes that contain paclitaxel (PTX) can penetrate the brain and suppress the recurrence of glioma in mice whose tumour has been resected surgically, and this NE-mediated delivery of drugs efficiently slows the recurrent growth of tumours. Expand
Altered Expression of Synaptotagmin I In Temporal Lobe Tissue of Patients With Refractory Epilepsy
The expression of Synaptotagmin I in refractory epilepsy group was significantly higher than that in the control and non-refractory epileptory epilepsy groups, and this findings provide new information in the epileptogenesis of refractor epilepsy, and suggest that Synaptosynthesis I might be involved in human refractary epilepsy. Expand
Involucratustones A-C: Unprecedented Sesquiterpene Dimers Containing Multiple Contiguous Quaternary Carbons from Stahlianthus involucratus.
Involucratustones A-C (1-3), three cadinane dimers containing multiple contiguous quaternary carbons, were isolated from the rhizomes of Stahlianthus involucratus and showed notable anti-inflammatory effect. Expand
Multifunctional tacrine-flavonoid hybrids with cholinergic, β-amyloid-reducing, and metal chelating properties for the treatment of Alzheimer's disease.
A new series of tacrine-flavonoid hybrids (13a-u) had been designed, synthesized, and evaluated as multifunctional cholinesterase (ChE) inhibitors against Alzheimer's disease (AD). In vitro studiesExpand
Rhodomyrtials A and B, Two Meroterpenoids with a Triketone-Sesquiterpene-Triketone Skeleton from Rhodomyrtus tomentosa: Structural Elucidation and Biomimetic Synthesis.
Two unprecedented triketone-sesquiterpene-triketone adducts and five biogenetically related intermediates were isolated from the leaves of Rhodomyrtus tomentosa and exhibited potent metastatic inhibitory activity against DLD-1 cells by suppressing the activation of matrix metalloproteinase (MMP)-2 and MMP-9. Expand
[Study of relationship between inflammatory response and apoptosis in perihematoma region in patients with intracerebral hemorrhage].
There is a close relationship between inflammatory response and apoptosis and tissue damage in the perihematoma area in patients with intracerebral hemorrhage. Expand
Protective effects of oleanolic acid on cerebral ischemic damage in vivo and H2O2-induced injury in vitro
Results demonstrate that oleanolic acid effectively alleviates cerebral ischemic damage in vivo and oxidative injury in vitro, which may be in part due to the modulation of endogenous antioxidants and the improvement of mitochondrial function. Expand
Hippocampal PPARδ Overexpression or Activation Represses Stress-Induced Depressive Behaviors and Enhances Neurogenesis
The results suggest that hippocampal PPARδ upregulation represses stress-induced depressive behaviors, accompanied by enhancement of neurogenesis in the hippocampi of mice. Expand
Lipid-lowering effects of oleanolic acid in hyperlipidemic patients.
Clinical evidence was shown that OA could improve hyperlipidemia and a new insight was unveiled into the molecular mechanisms underlying the pharmacological effect of OA on hyper Lipidemia. Expand