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Modern analytical techniques in metabolomics analysis.
Metabolomics is the comprehensive assessment of endogenous metabolites and attempts to systematically identify and quantify metabolites from a biological sample. Small-molecule metabolites have an… Expand
Urinary metabolic profiling identifies a key role for glycocholic acid in human liver cancer by ultra-performance liquid-chromatography coupled with high-definition mass spectrometry.
- A. Zhang, H. Sun, Guang-li Yan, Ying Han, Y. Ye, X. Wang
- Biology, Medicine
- Clinica chimica acta; international journal of…
- 15 March 2013
BACKGROUND Metabolomics has been proposed to be a hallmark of cancer, yet a systematic characterization of a metabolite and metabolic pathways in human hepatocarcinoma (HCC) remains a challenge. … Expand
Advancing Drug Discovery and Development from Active Constituents of Yinchenhao Tang, a Famous Traditional Chinese Medicine Formula
- A. Zhang, H. Sun, Shi Qiu, X. Wang
- Evidence-based complementary and alternative…
- 26 September 2013
Traditional Chinese medicine (TCM) formula has been playing a very important role in health protection and disease control for thousands of years. Guided by TCM syndrome theories, formula are… Expand
Recent and potential developments of biofluid analyses in metabolomics.
Metabolomics, one of the 'omic' sciences in systems biology, is the global assessment and validation of endogenous small-molecule metabolites within a biologic system. Analysis of these key… Expand
Ultra-performance liquid chromatography coupled to mass spectrometry as a sensitive and powerful technology for metabolomic studies.
- X. Wang, H. Sun, A. Zhang, P. Wang, Ying Han
- Chemistry, Medicine
- Journal of separation science
- 1 December 2011
Metabolomics is the comprehensive assessment of endogenous metabolites of a biological system. These large-scale analyses of metabolites are intimately bound to advancements in ultra-performance… Expand
Metabolomic Analysis of Key Regulatory Metabolites in Hepatitis C Virus–infected Tree Shrews*
- H. Sun, A. Zhang, +7 authors X. Wang
- Biology, Medicine
- Molecular & Cellular Proteomics
- 20 December 2012
Metabolomics is a powerful new technology that allows the assessment of global low-molecular-weight metabolites in a biological system and which shows great potential in biomarker discovery. Analysis… Expand
Metabolomics study on Fuzi and its processed products using ultra-performance liquid-chromatography/electrospray-ionization synapt high-definition mass spectrometry coupled with pattern recognition…
The lateral root of Aconitum carmichaelii Debx is named "Fuzi" which is widely distributed across Asia and North America and has been used to relieve joint pain and treat rheumatic diseases for over… Expand
The application of metabolomics in traditional Chinese medicine opens up a dialogue between Chinese and Western medicine
Metabolomics provides an opportunity to develop the systematic analysis of the metabolites and has been applied to discovering biomarkers and perturbed pathways which can clarify the action mechanism… Expand
Urinary Metabolic Biomarker and Pathway Study of Hepatitis B Virus Infected Patients Based on UPLC-MS System
Hepatitis B virus (HBV) is the fatal consequence of chronic hepatitis, and lack of biomarkers has been a long standing bottleneck in the clinical diagnosis. Metabolomics concerns with comprehensive… Expand
Proteomics study on the hepatoprotective effects of traditional Chinese medicine formulae Yin-Chen-Hao-Tang by a combination of two-dimensional polyacrylamide gel electrophoresis and matrix-assisted…
- H. Sun, A. Zhang, +4 authors X. Wang
- Chemistry, Medicine
- Journal of pharmaceutical and biomedical analysis
- 5 March 2013
Proteomics can bring breakthroughs in the study of traditional Chinese medicine (TCM). Yin-Chen-Hao-Tang (YCHT), a famous TCM formulae, has been used to alleviate various types of liver injury.… Expand